Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study
Identification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cog...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1125114/full |
| _version_ | 1797856370354028544 |
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| author | Jeannette R. Mahoney Helena M. Blumen Helena M. Blumen Pierfilippo De Sanctis Pierfilippo De Sanctis Roman Fleysher Carolina Frankini Alexandria Hoang Matthew J. Hoptman Matthew J. Hoptman Runqiu Jin Michael Lipton Michael Lipton Michael Lipton Michael Lipton Valerie Nunez Lital Twizer Naomi Uy Ana Valdivia Tanya Verghese Cuiling Wang Cuiling Wang Erica F. Weiss Erica F. Weiss Jessica Zwerling Joe Verghese Joe Verghese Joe Verghese |
| author_facet | Jeannette R. Mahoney Helena M. Blumen Helena M. Blumen Pierfilippo De Sanctis Pierfilippo De Sanctis Roman Fleysher Carolina Frankini Alexandria Hoang Matthew J. Hoptman Matthew J. Hoptman Runqiu Jin Michael Lipton Michael Lipton Michael Lipton Michael Lipton Valerie Nunez Lital Twizer Naomi Uy Ana Valdivia Tanya Verghese Cuiling Wang Cuiling Wang Erica F. Weiss Erica F. Weiss Jessica Zwerling Joe Verghese Joe Verghese Joe Verghese |
| author_sort | Jeannette R. Mahoney |
| collection | DOAJ |
| description | Identification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cognitive functions, such as memory. Previous investigations have not comprehensively examined the interplay of sensory, cognitive, and motor dysfunction with relation to AD progression. The ability to successfully integrate multisensory information across multiple sensory modalities is a vital aspect of everyday functioning and mobility. Our research suggests that multisensory integration, specifically visual-somatosensory integration (VSI), could be used as a novel marker for preclinical AD given previously reported associations with important motor (balance, gait, and falls) and cognitive (attention) outcomes in aging. While the adverse effect of dementia and cognitive impairment on the relationship between multisensory functioning and motor outcomes has been highlighted, the underlying functional and neuroanatomical networks are still unknown. In what follows we detail the protocol for our study, named The VSI Study, which is strategically designed to determine whether preclinical AD is associated with neural disruptions in subcortical and cortical areas that concurrently modulate multisensory, cognitive, and motor functions resulting in mobility decline. In this longitudinal observational study, a total of 208 community-dwelling older adults with and without preclinical AD will be recruited and monitored yearly. Our experimental design affords assessment of multisensory integration as a new behavioral marker for preclinical AD; identification of functional neural networks involved in the intersection of sensory, motor, and cognitive functioning; and determination of the impact of early AD on future mobility declines, including incident falls. Results of The VSI Study will guide future development of innovative multisensory-based interventions aimed at preventing disability and optimizing independence in pathological aging. |
| first_indexed | 2024-04-09T20:39:19Z |
| format | Article |
| id | doaj.art-ac787c6f4ec74a24b07c3f7ccff86ade |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T20:39:19Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ac787c6f4ec74a24b07c3f7ccff86ade2023-03-30T06:06:50ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.11251141125114Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI studyJeannette R. Mahoney0Helena M. Blumen1Helena M. Blumen2Pierfilippo De Sanctis3Pierfilippo De Sanctis4Roman Fleysher5Carolina Frankini6Alexandria Hoang7Matthew J. Hoptman8Matthew J. Hoptman9Runqiu Jin10Michael Lipton11Michael Lipton12Michael Lipton13Michael Lipton14Valerie Nunez15Lital Twizer16Naomi Uy17Ana Valdivia18Tanya Verghese19Cuiling Wang20Cuiling Wang21Erica F. Weiss22Erica F. Weiss23Jessica Zwerling24Joe Verghese25Joe Verghese26Joe Verghese27Department of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, United StatesGruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDivision of Clinical Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, United StatesDepartment of Psychiatry, NYU Grossman School of Medicine, New York, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesGruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Radiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United StatesThe Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Psychiatry and Behavioral Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United States0Department of Radiology, Division of Nuclear Medicine, Montefiore Medical Center, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United States1Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United States2Center of Aging Brain, Montefiore Medical Center, Yonkers, NY, United States2Center of Aging Brain, Montefiore Medical Center, Yonkers, NY, United StatesDepartment of Neurology, Division of Cognitive and Motor Aging, Albert Einstein College of Medicine, Bronx, NY, United StatesDepartment of Medicine, Division of Geriatrics, Albert Einstein College of Medicine, Bronx, NY, United States2Center of Aging Brain, Montefiore Medical Center, Yonkers, NY, United StatesIdentification of novel, non-invasive, non-cognitive based markers of Alzheimer’s disease (AD) and related dementias are a global priority. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher-order cognitive functions, such as memory. Previous investigations have not comprehensively examined the interplay of sensory, cognitive, and motor dysfunction with relation to AD progression. The ability to successfully integrate multisensory information across multiple sensory modalities is a vital aspect of everyday functioning and mobility. Our research suggests that multisensory integration, specifically visual-somatosensory integration (VSI), could be used as a novel marker for preclinical AD given previously reported associations with important motor (balance, gait, and falls) and cognitive (attention) outcomes in aging. While the adverse effect of dementia and cognitive impairment on the relationship between multisensory functioning and motor outcomes has been highlighted, the underlying functional and neuroanatomical networks are still unknown. In what follows we detail the protocol for our study, named The VSI Study, which is strategically designed to determine whether preclinical AD is associated with neural disruptions in subcortical and cortical areas that concurrently modulate multisensory, cognitive, and motor functions resulting in mobility decline. In this longitudinal observational study, a total of 208 community-dwelling older adults with and without preclinical AD will be recruited and monitored yearly. Our experimental design affords assessment of multisensory integration as a new behavioral marker for preclinical AD; identification of functional neural networks involved in the intersection of sensory, motor, and cognitive functioning; and determination of the impact of early AD on future mobility declines, including incident falls. Results of The VSI Study will guide future development of innovative multisensory-based interventions aimed at preventing disability and optimizing independence in pathological aging.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1125114/fullmultisensory integrationsensory processingmobilitycognitionAlzheimer’s disease |
| spellingShingle | Jeannette R. Mahoney Helena M. Blumen Helena M. Blumen Pierfilippo De Sanctis Pierfilippo De Sanctis Roman Fleysher Carolina Frankini Alexandria Hoang Matthew J. Hoptman Matthew J. Hoptman Runqiu Jin Michael Lipton Michael Lipton Michael Lipton Michael Lipton Valerie Nunez Lital Twizer Naomi Uy Ana Valdivia Tanya Verghese Cuiling Wang Cuiling Wang Erica F. Weiss Erica F. Weiss Jessica Zwerling Joe Verghese Joe Verghese Joe Verghese Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study Frontiers in Aging Neuroscience multisensory integration sensory processing mobility cognition Alzheimer’s disease |
| title | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
| title_full | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
| title_fullStr | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
| title_full_unstemmed | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
| title_short | Visual-somatosensory integration (VSI) as a novel marker of Alzheimer’s disease: A comprehensive overview of the VSI study |
| title_sort | visual somatosensory integration vsi as a novel marker of alzheimer s disease a comprehensive overview of the vsi study |
| topic | multisensory integration sensory processing mobility cognition Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1125114/full |
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