Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study
Background and study aims Evaluation of longitudinal tumor extent is indispensable for curative surgical treatment of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness and feasibility of cholangioscopic-guided mapping biopsy using a newly developed peroral digital...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2018-02-01
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| Series: | Endoscopy International Open |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-117949 |
| _version_ | 1818332188792324096 |
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| author | Takahisa Ogawa Kei Ito Shinsuke Koshita Yoshihide Kanno Kaori Masu Hiroaki Kusunose Toshitaka Sakai Toji Murabayashi Sho Hasegawa Yutaka Noda |
| author_facet | Takahisa Ogawa Kei Ito Shinsuke Koshita Yoshihide Kanno Kaori Masu Hiroaki Kusunose Toshitaka Sakai Toji Murabayashi Sho Hasegawa Yutaka Noda |
| author_sort | Takahisa Ogawa |
| collection | DOAJ |
| description | Background and study aims Evaluation of longitudinal tumor extent is indispensable for curative surgical treatment of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness and feasibility of cholangioscopic-guided mapping biopsy using a newly developed peroral digital cholangioscope, SpyGlass DS (SpyDS), for preoperative evaluation of extrahepatic cholangiocarcinoma.
Patients and methods Thirteen patients (mean age, 75 years; male 10, female 3) with extrahepatic cholangiocarcinoma who underwent cholangioscopic-guided mapping biopsy using SpyDS for preoperative evaluation were included in this study. Successful cholangioscopic-guided mapping biopsy was defined as the acquisition of specimens sufficient for histopathological diagnosis.
Results The mean number of biopsies was 5 per patient. The overall success rate for cholangioscopic-guided mapping biopsy was 88 % (59/67). The success rate for cholangioscopic-guided mapping biopsy from the confluence of the right and left hepatic ducts was 89 %, that from the B4 confluence was 93 %, that from the confluence of the right anterior and right posterior segmental ducts was 86 %, that from the intrapancreatic common bile duct was 67 %, and that from the main lesion was 100 %. The overall diagnostic accuracy of longitudinal tumor extent at the hepatic side, the duodenal side and overall by cholangioscopic findings and mapping biopsy, was 88 % (7/8), 88 % (7/8) and 88 % (7/8), respectively. Assessment according to location of the main lesion revealed that diagnostic accuracy in the patients with distal bile duct carcinoma was 100 % (5/5) and that in patients with perihilar bile duct carcinoma was 66 % (2/3). Complications after the procedure did not occur in any patients.
Conclusions Cholangioscopic-guided mapping biopsy using SpyDS is thought to be feasible for preoperative evaluation of extrahepatic cholangiocarcinoma. |
| first_indexed | 2024-12-13T13:31:47Z |
| format | Article |
| id | doaj.art-ac78e1178f6e4cedb19d0f2bcf0b88e2 |
| institution | Directory Open Access Journal |
| issn | 2364-3722 2196-9736 |
| language | English |
| last_indexed | 2024-12-13T13:31:47Z |
| publishDate | 2018-02-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Endoscopy International Open |
| spelling | doaj.art-ac78e1178f6e4cedb19d0f2bcf0b88e22022-12-21T23:44:08ZengGeorg Thieme Verlag KGEndoscopy International Open2364-37222196-97362018-02-010602E199E20410.1055/s-0043-117949Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot studyTakahisa Ogawa0Kei Ito1Shinsuke Koshita2Yoshihide Kanno3Kaori Masu4Hiroaki Kusunose5Toshitaka Sakai6Toji Murabayashi7Sho Hasegawa8Yutaka Noda9Department of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanDepartment of Gastroenterology, Sendai City Medical Center, Sendai, JapanBackground and study aims Evaluation of longitudinal tumor extent is indispensable for curative surgical treatment of extrahepatic cholangiocarcinoma. The aim of this study was to evaluate the usefulness and feasibility of cholangioscopic-guided mapping biopsy using a newly developed peroral digital cholangioscope, SpyGlass DS (SpyDS), for preoperative evaluation of extrahepatic cholangiocarcinoma. Patients and methods Thirteen patients (mean age, 75 years; male 10, female 3) with extrahepatic cholangiocarcinoma who underwent cholangioscopic-guided mapping biopsy using SpyDS for preoperative evaluation were included in this study. Successful cholangioscopic-guided mapping biopsy was defined as the acquisition of specimens sufficient for histopathological diagnosis. Results The mean number of biopsies was 5 per patient. The overall success rate for cholangioscopic-guided mapping biopsy was 88 % (59/67). The success rate for cholangioscopic-guided mapping biopsy from the confluence of the right and left hepatic ducts was 89 %, that from the B4 confluence was 93 %, that from the confluence of the right anterior and right posterior segmental ducts was 86 %, that from the intrapancreatic common bile duct was 67 %, and that from the main lesion was 100 %. The overall diagnostic accuracy of longitudinal tumor extent at the hepatic side, the duodenal side and overall by cholangioscopic findings and mapping biopsy, was 88 % (7/8), 88 % (7/8) and 88 % (7/8), respectively. Assessment according to location of the main lesion revealed that diagnostic accuracy in the patients with distal bile duct carcinoma was 100 % (5/5) and that in patients with perihilar bile duct carcinoma was 66 % (2/3). Complications after the procedure did not occur in any patients. Conclusions Cholangioscopic-guided mapping biopsy using SpyDS is thought to be feasible for preoperative evaluation of extrahepatic cholangiocarcinoma.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-117949 |
| spellingShingle | Takahisa Ogawa Kei Ito Shinsuke Koshita Yoshihide Kanno Kaori Masu Hiroaki Kusunose Toshitaka Sakai Toji Murabayashi Sho Hasegawa Yutaka Noda Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study Endoscopy International Open |
| title | Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study |
| title_full | Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study |
| title_fullStr | Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study |
| title_full_unstemmed | Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study |
| title_short | Usefulness of cholangioscopic-guided mapping biopsy using SpyGlass DS for preoperative evaluation of extrahepatic cholangiocarcinoma: a pilot study |
| title_sort | usefulness of cholangioscopic guided mapping biopsy using spyglass ds for preoperative evaluation of extrahepatic cholangiocarcinoma a pilot study |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-117949 |
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