Carbazole Derivatives as Antiviral Agents: An Overview
Viruses represent the most common cause of infectious diseases worldwide and those with rapid propagation and high infection rates cause human and animal pandemics. These fast-spreading diseases are generally treated with antiviral drugs but, often, drug resistance occurs because of the ability of t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/10/1912 |
| _version_ | 1818303276220678144 |
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| author | Anna Caruso Jessica Ceramella Domenico Iacopetta Carmela Saturnino Maria Vittoria Mauro Rosalinda Bruno Stefano Aquaro Maria Stefania Sinicropi |
| author_facet | Anna Caruso Jessica Ceramella Domenico Iacopetta Carmela Saturnino Maria Vittoria Mauro Rosalinda Bruno Stefano Aquaro Maria Stefania Sinicropi |
| author_sort | Anna Caruso |
| collection | DOAJ |
| description | Viruses represent the most common cause of infectious diseases worldwide and those with rapid propagation and high infection rates cause human and animal pandemics. These fast-spreading diseases are generally treated with antiviral drugs but, often, drug resistance occurs because of the ability of the pathogens to mutate rapidly and become less susceptible to the treatments. Even though new antivirals have been approved, e.g., in HIV (human immunodeficiency virus) and HCV (hepatitis C virus) therapeutic areas, the need to dispose of new pharmaceutical tools for the management of infections that still have no treatment is of growing interest. In these areas, carbazole represents an important privileged scaffold in drug discovery. Many compounds with a carbazolic core have been developed and some of them have shown antiviral activity. This review provides an overview on some already known carbazole derivatives, pointing the attention on the running progresses in identifying new molecules with carbazolic structure, that have shown interesting and encouraging in vitro and in vivo properties. These drugs may be exploited as valid alternatives in antiviral therapy. |
| first_indexed | 2024-12-13T05:52:13Z |
| format | Article |
| id | doaj.art-ac7a20d2bbc643abae6da6d31b6776cd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-13T05:52:13Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ac7a20d2bbc643abae6da6d31b6776cd2022-12-21T23:57:31ZengMDPI AGMolecules1420-30492019-05-012410191210.3390/molecules24101912molecules24101912Carbazole Derivatives as Antiviral Agents: An OverviewAnna Caruso0Jessica Ceramella1Domenico Iacopetta2Carmela Saturnino3Maria Vittoria Mauro4Rosalinda Bruno5Stefano Aquaro6Maria Stefania Sinicropi7Department of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Science, University of Basilicata, 85100 Potenza, ItalyUOC Microbiologia e Virologia AO Annunziata, 87100 Cosenza, ItalyDepartment of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy, Health & Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, ItalyViruses represent the most common cause of infectious diseases worldwide and those with rapid propagation and high infection rates cause human and animal pandemics. These fast-spreading diseases are generally treated with antiviral drugs but, often, drug resistance occurs because of the ability of the pathogens to mutate rapidly and become less susceptible to the treatments. Even though new antivirals have been approved, e.g., in HIV (human immunodeficiency virus) and HCV (hepatitis C virus) therapeutic areas, the need to dispose of new pharmaceutical tools for the management of infections that still have no treatment is of growing interest. In these areas, carbazole represents an important privileged scaffold in drug discovery. Many compounds with a carbazolic core have been developed and some of them have shown antiviral activity. This review provides an overview on some already known carbazole derivatives, pointing the attention on the running progresses in identifying new molecules with carbazolic structure, that have shown interesting and encouraging in vitro and in vivo properties. These drugs may be exploited as valid alternatives in antiviral therapy.https://www.mdpi.com/1420-3049/24/10/1912carbazoletetrahydrocarbazoleantiviral agents |
| spellingShingle | Anna Caruso Jessica Ceramella Domenico Iacopetta Carmela Saturnino Maria Vittoria Mauro Rosalinda Bruno Stefano Aquaro Maria Stefania Sinicropi Carbazole Derivatives as Antiviral Agents: An Overview Molecules carbazole tetrahydrocarbazole antiviral agents |
| title | Carbazole Derivatives as Antiviral Agents: An Overview |
| title_full | Carbazole Derivatives as Antiviral Agents: An Overview |
| title_fullStr | Carbazole Derivatives as Antiviral Agents: An Overview |
| title_full_unstemmed | Carbazole Derivatives as Antiviral Agents: An Overview |
| title_short | Carbazole Derivatives as Antiviral Agents: An Overview |
| title_sort | carbazole derivatives as antiviral agents an overview |
| topic | carbazole tetrahydrocarbazole antiviral agents |
| url | https://www.mdpi.com/1420-3049/24/10/1912 |
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