Effect of Intensive Atorvastatin Therapy on Periprocedural Phosphatase and Tension Homolog Deleted on Chromosome Ten (PTEN) Expression in CD4+T Lymphocytes of Patients with Unstable Angina Undergoing Percutaneous Coronary Intervention
Objectives: To investigate the effects of intensive atorvastatin therapy on Phosphatase and tension homolog deleted on chromosome ten (PTEN) expression by CD4+ T lymphocytes in patients with unstable angina (UA) who received percutaneous coronary intervention (PCI). Methods: All patients with UA wer...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Barcaray International
2016-01-01
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| Series: | International Cardiovascular Forum Journal |
| Subjects: | |
| Online Access: | http://icfjournal.org/index.php/icfj/article/view/246/Wang%20246%20pp85-90 |
| Summary: | Objectives: To investigate the effects of intensive atorvastatin therapy on Phosphatase and tension homolog deleted on chromosome ten (PTEN) expression by CD4+ T lymphocytes in patients with unstable angina (UA) who received percutaneous coronary intervention (PCI).
Methods: All patients with UA were randomly allocated to pretreatment with intensive atorvastatin (ATV, 80mg 12h before PCI, with a further 20mg every day after PCI, n = 56) or conventional dose (control group, only 20 mg/day, n = 56). Circulating CD4+ T cells were subsequently obtained prior to PCI and 18–24 h after successful PCI, using a magnetic cell sorting system. Plasma cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), high sensitivity C reactive protein (hsCRP), interleukin-10 (IL-10) and tumor necrosis factor a(TNF-a) levels were measured just prior to the PCI and 18–24 h after PCI. PTEN mRNA and protein were determined by Real-time PCR and western blots, respectively.
Results: PTEN mRNA and protein were dramatically decreased in ATV group (p < 0.05). In contrast, TNF-and hsCRP significantly increased following PCI in both groups, with the ATV group being higher than control group (p < 0.05). IL-10 also markedly increased following PCI for the two groups. However, higher values were associated with the ATV group (p < 0.05). Compared to the control group, the incidence of elevated cTnI levels post-PCI was lower in the ATV group (p < 0.05); however, no difference could be found between the two groups regarding the incidence of elevated CK-MB post-PCI (p >0.05).
Conclusions: Intensive atorvastatin treatment reduced the post-PCI myocardial inflammatory response in patients with UA, possibly by enhancing PTEN expression in CD4+ T lymphocytes. |
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| ISSN: | 2410-2636 2409-3424 |