Regulatory mechanism of macrophage polarization based on Hippo pathway
Macrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279591/full |
| _version_ | 1797449163373281280 |
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| author | Yuanqing Liu Yina An Gebin Li Shuaiyu Wang Shuaiyu Wang |
| author_facet | Yuanqing Liu Yina An Gebin Li Shuaiyu Wang Shuaiyu Wang |
| author_sort | Yuanqing Liu |
| collection | DOAJ |
| description | Macrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and the anti-tumor phenotype M1. The Hippo signaling pathway affects the development of cancer and other diseases through various biological processes, such as inhibition of cell growth. In this review, we focus on immune cells within the microenvironment of tumors and other diseases, and the role of the Hippo pathway in tumors on macrophage polarization in the tumor microenvironment (TME) and other diseases. |
| first_indexed | 2024-03-09T14:20:52Z |
| format | Article |
| id | doaj.art-ac7ca13d84b54517ab88bb2dd4390c35 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T14:20:52Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ac7ca13d84b54517ab88bb2dd4390c352023-11-28T13:41:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12795911279591Regulatory mechanism of macrophage polarization based on Hippo pathwayYuanqing Liu0Yina An1Gebin Li2Shuaiyu Wang3Shuaiyu Wang4The Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaThe Clinical Department, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaCenter of Research and Innovation of Chinese Traditional Veterinary Medicine, China Agricultural University, Beijing, ChinaMacrophages are found to infiltrate and migrate in a large number of Tumor-associated macrophages (TMEs) and other macrophages in the microenvironment of tumors and related diseases, and undergo phenotypic changes in response to a variety of cytokines, mainly including the primary phenotype M2 and the anti-tumor phenotype M1. The Hippo signaling pathway affects the development of cancer and other diseases through various biological processes, such as inhibition of cell growth. In this review, we focus on immune cells within the microenvironment of tumors and other diseases, and the role of the Hippo pathway in tumors on macrophage polarization in the tumor microenvironment (TME) and other diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279591/fullmacrophagesHippotumor microenvironmentpolarizationregulation |
| spellingShingle | Yuanqing Liu Yina An Gebin Li Shuaiyu Wang Shuaiyu Wang Regulatory mechanism of macrophage polarization based on Hippo pathway Frontiers in Immunology macrophages Hippo tumor microenvironment polarization regulation |
| title | Regulatory mechanism of macrophage polarization based on Hippo pathway |
| title_full | Regulatory mechanism of macrophage polarization based on Hippo pathway |
| title_fullStr | Regulatory mechanism of macrophage polarization based on Hippo pathway |
| title_full_unstemmed | Regulatory mechanism of macrophage polarization based on Hippo pathway |
| title_short | Regulatory mechanism of macrophage polarization based on Hippo pathway |
| title_sort | regulatory mechanism of macrophage polarization based on hippo pathway |
| topic | macrophages Hippo tumor microenvironment polarization regulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1279591/full |
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