Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis
Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2016-06-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| Subjects: | |
| Online Access: | https://www.sci-notes.ru/jour/article/view/324 |
| Summary: | Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis. |
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| ISSN: | 1607-4181 2541-8807 |