Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis
Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Academician I.P. Pavlov First St. Petersburg State Medical University
2016-06-01
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| Series: | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
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| Online Access: | https://www.sci-notes.ru/jour/article/view/324 |
| _version_ | 1826560817373380608 |
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| author | Z. I. Ionova E. G. Sergeeva O. A. Berkovich S. N. Pchelina E. I. Baranova |
| author_facet | Z. I. Ionova E. G. Sergeeva O. A. Berkovich S. N. Pchelina E. I. Baranova |
| author_sort | Z. I. Ionova |
| collection | DOAJ |
| description | Literature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis. |
| first_indexed | 2024-03-12T04:49:05Z |
| format | Article |
| id | doaj.art-ac7cc3ac21df4835b7dc31ba17807b0a |
| institution | Directory Open Access Journal |
| issn | 1607-4181 2541-8807 |
| language | Russian |
| last_indexed | 2025-03-14T09:22:18Z |
| publishDate | 2016-06-01 |
| publisher | Academician I.P. Pavlov First St. Petersburg State Medical University |
| record_format | Article |
| series | Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова |
| spelling | doaj.art-ac7cc3ac21df4835b7dc31ba17807b0a2025-03-02T11:44:13ZrusAcademician I.P. Pavlov First St. Petersburg State Medical UniversityУчёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова1607-41812541-88072016-06-01232152010.24884/1607-4181-2016-23-2-15-20299Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosisZ. I. Ionova0E. G. Sergeeva1O. A. Berkovich2S. N. Pchelina3E. I. Baranova4Pavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical UniversityLiterature review is devoted to the pathogenesis of atherosclerosis and pathogenetic mechanisms that determine the value of peroxisome proliferator-activated receptor (PPAR) in atherogenesis. PPAR α and ϒ-2 are nuclear receptors that regulate lipid and glucose metabolism, and immune inflammation in the vascular wall and play a significant role in the pathogenesis of atherosclerosis. Thiazolidindiones, fibrates, ω-3 polyunsaturated fatty acids, statins, and aleglitezar, affecting PPAR α and ϒ-2 can prevent development and progression of atherosclerosis and may be used for primary and secondary prophylaxis of atherosclerosis.https://www.sci-notes.ru/jour/article/view/324рецепторы активатора пролиферации пероксисомpparтиазолидиндионыфибратыомега-3 пнжкстатиныалеглитазар |
| spellingShingle | Z. I. Ionova E. G. Sergeeva O. A. Berkovich S. N. Pchelina E. I. Baranova Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова рецепторы активатора пролиферации пероксисом ppar тиазолидиндионы фибраты омега-3 пнжк статины алеглитазар |
| title | Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis |
| title_full | Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis |
| title_fullStr | Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis |
| title_full_unstemmed | Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis |
| title_short | Role of peroxisome proliferator-activated receptor α and ϒ-2 in primary and secondary prophylaxis of atherosclerosis |
| title_sort | role of peroxisome proliferator activated receptor α and ϒ 2 in primary and secondary prophylaxis of atherosclerosis |
| topic | рецепторы активатора пролиферации пероксисом ppar тиазолидиндионы фибраты омега-3 пнжк статины алеглитазар |
| url | https://www.sci-notes.ru/jour/article/view/324 |
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