Effects of Ondansetron on Xylazine Induced Emesis in Cats
Objective- Vomiting frequently is reported after xylazine administration in cats. This study evaluates prophylactic antiemetic efficacy of ondansetron in cats sedated with xylazine HCl.<br /> Design-Experimental study.<br /> Animals- Six healthy adult cats from both genders were selected...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iranian Veterinary Surgery Association (IVSA)
2010-08-01
|
| Series: | Iranian Journal of Veterinary Surgery |
| Subjects: | |
| Online Access: | http://www.ivsajournals.com/article_3144_47f24e768578ea679044e57728b56783.pdf |
| _version_ | 1818338779389231104 |
|---|---|
| author | Seyedhosein Jarolmasjed Saeed Kolahian |
| author_facet | Seyedhosein Jarolmasjed Saeed Kolahian |
| author_sort | Seyedhosein Jarolmasjed |
| collection | DOAJ |
| description | Objective- Vomiting frequently is reported after xylazine administration in cats. This study evaluates prophylactic antiemetic efficacy of ondansetron in cats sedated with xylazine HCl.<br /> Design-Experimental study.<br /> Animals- Six healthy adult cats from both genders were selected for the study.<br /> Interventions- Intramuscular injection of normal saline was administered an hour before intramuscular injection of xylazine (0.66 mg/kg) on day 0 (control treatment). Ondansetron was injected in three increasing dosages (0.2, 0.4 and 0.8 mg/kg) an hour prior to administration of xylazine on days 7, 14 and 21, respectively (experimental treatments). All the cats were fed with commercial food after ondansetron or saline injection.<br /> Measurements and Main Results- They were monitored after injection of xylazine for thirty minutes to record the onset of first emetic response, frequency of emetic episodes and the onset of recumbency. All data were analyzed using Wilcoxon signed-rank test. Prior treatment with each dosage of ondansetron significantly reduced the frequency of emetic episodes (p<0.05). Ondansetron administration prior to xylazine injection didn’t increase the time until onset of the first emetic episode and also onset of recumbency at any of mentioned dosages.<br /> Conclusions and Clinical Relevance- Ondansetron may be used as a prophylactic antiemetic in cats sedated with xylazine HCl. |
| first_indexed | 2024-12-13T15:16:32Z |
| format | Article |
| id | doaj.art-ac7dfca97a7843d38927c50a1b23f890 |
| institution | Directory Open Access Journal |
| issn | 2008-3033 2008-3033 |
| language | English |
| last_indexed | 2024-12-13T15:16:32Z |
| publishDate | 2010-08-01 |
| publisher | Iranian Veterinary Surgery Association (IVSA) |
| record_format | Article |
| series | Iranian Journal of Veterinary Surgery |
| spelling | doaj.art-ac7dfca97a7843d38927c50a1b23f8902022-12-21T23:40:41ZengIranian Veterinary Surgery Association (IVSA)Iranian Journal of Veterinary Surgery2008-30332008-30332010-08-01051-263703144Effects of Ondansetron on Xylazine Induced Emesis in CatsSeyedhosein Jarolmasjed0Saeed Kolahian1Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran.Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran.Objective- Vomiting frequently is reported after xylazine administration in cats. This study evaluates prophylactic antiemetic efficacy of ondansetron in cats sedated with xylazine HCl.<br /> Design-Experimental study.<br /> Animals- Six healthy adult cats from both genders were selected for the study.<br /> Interventions- Intramuscular injection of normal saline was administered an hour before intramuscular injection of xylazine (0.66 mg/kg) on day 0 (control treatment). Ondansetron was injected in three increasing dosages (0.2, 0.4 and 0.8 mg/kg) an hour prior to administration of xylazine on days 7, 14 and 21, respectively (experimental treatments). All the cats were fed with commercial food after ondansetron or saline injection.<br /> Measurements and Main Results- They were monitored after injection of xylazine for thirty minutes to record the onset of first emetic response, frequency of emetic episodes and the onset of recumbency. All data were analyzed using Wilcoxon signed-rank test. Prior treatment with each dosage of ondansetron significantly reduced the frequency of emetic episodes (p<0.05). Ondansetron administration prior to xylazine injection didn’t increase the time until onset of the first emetic episode and also onset of recumbency at any of mentioned dosages.<br /> Conclusions and Clinical Relevance- Ondansetron may be used as a prophylactic antiemetic in cats sedated with xylazine HCl.http://www.ivsajournals.com/article_3144_47f24e768578ea679044e57728b56783.pdfCatsOndansetronSedationVomitingXylazine |
| spellingShingle | Seyedhosein Jarolmasjed Saeed Kolahian Effects of Ondansetron on Xylazine Induced Emesis in Cats Iranian Journal of Veterinary Surgery Cats Ondansetron Sedation Vomiting Xylazine |
| title | Effects of Ondansetron on Xylazine Induced Emesis in Cats |
| title_full | Effects of Ondansetron on Xylazine Induced Emesis in Cats |
| title_fullStr | Effects of Ondansetron on Xylazine Induced Emesis in Cats |
| title_full_unstemmed | Effects of Ondansetron on Xylazine Induced Emesis in Cats |
| title_short | Effects of Ondansetron on Xylazine Induced Emesis in Cats |
| title_sort | effects of ondansetron on xylazine induced emesis in cats |
| topic | Cats Ondansetron Sedation Vomiting Xylazine |
| url | http://www.ivsajournals.com/article_3144_47f24e768578ea679044e57728b56783.pdf |
| work_keys_str_mv | AT seyedhoseinjarolmasjed effectsofondansetrononxylazineinducedemesisincats AT saeedkolahian effectsofondansetrononxylazineinducedemesisincats |