Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes
A novel biologically active thiosemicarbazide derivative ligand <i>L</i> (<i>N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide</i>) and a series of its five metal(II) complexes, namely: [Co(L)Cl<sub>2</sub>], [Ni(L)Cl<sub>2</sub>(H<sub>2</s...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/2703 |
| _version_ | 1797503756588285952 |
|---|---|
| author | Bartłomiej Rogalewicz Alina Climova Ekaterina Pivovarova Jarosław Sukiennik Kamila Czarnecka Paweł Szymański Małgorzata Szczesio Katarzyna Gas Maciej Sawicki Monika Pitucha Agnieszka Czylkowska |
| author_facet | Bartłomiej Rogalewicz Alina Climova Ekaterina Pivovarova Jarosław Sukiennik Kamila Czarnecka Paweł Szymański Małgorzata Szczesio Katarzyna Gas Maciej Sawicki Monika Pitucha Agnieszka Czylkowska |
| author_sort | Bartłomiej Rogalewicz |
| collection | DOAJ |
| description | A novel biologically active thiosemicarbazide derivative ligand <i>L</i> (<i>N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide</i>) and a series of its five metal(II) complexes, namely: [Co(L)Cl<sub>2</sub>], [Ni(L)Cl<sub>2</sub>(H<sub>2</sub>O)], [Cu(L)Cl<sub>2</sub>(H<sub>2</sub>O)], [Zn(L)Cl<sub>2</sub>] and [Cd(L)Cl<sub>2</sub>(H<sub>2</sub>O)] have been synthesized and thoroughly investigated. The physicochemical characterization of the newly obtained compounds has been performed using appropriate analytical techniques, such as <sup>1</sup>H and <sup>l3</sup>C nuclear magnetic resonance (NMR), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR) and magnetic measurements. In order to study the pharmacokinetic profile of the compounds, ADMET analysis was performed. The in vitro studies revealed that the synthesized compounds exhibit potent biological activity against A549 human cancer cell line. |
| first_indexed | 2024-03-10T03:54:53Z |
| format | Article |
| id | doaj.art-ac7e31dc1f6e469bb337d5588a018480 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:54:53Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ac7e31dc1f6e469bb337d5588a0184802023-11-23T08:48:22ZengMDPI AGMolecules1420-30492022-04-01279270310.3390/molecules27092703Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) ComplexesBartłomiej Rogalewicz0Alina Climova1Ekaterina Pivovarova2Jarosław Sukiennik3Kamila Czarnecka4Paweł Szymański5Małgorzata Szczesio6Katarzyna Gas7Maciej Sawicki8Monika Pitucha9Agnieszka Czylkowska10Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, PolandDepartment of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego 1, 90-151 Lodz, PolandInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandInstitute of Physics, Polish Academy of Sciences, Aleja Lotnikow 32/46, PL-02668 Warsaw, PolandIndependent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, PL-20093 Lublin, PolandInstitute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, PolandA novel biologically active thiosemicarbazide derivative ligand <i>L</i> (<i>N-[(phenylcarbamothioyl)amino]pyridine-3-carboxamide</i>) and a series of its five metal(II) complexes, namely: [Co(L)Cl<sub>2</sub>], [Ni(L)Cl<sub>2</sub>(H<sub>2</sub>O)], [Cu(L)Cl<sub>2</sub>(H<sub>2</sub>O)], [Zn(L)Cl<sub>2</sub>] and [Cd(L)Cl<sub>2</sub>(H<sub>2</sub>O)] have been synthesized and thoroughly investigated. The physicochemical characterization of the newly obtained compounds has been performed using appropriate analytical techniques, such as <sup>1</sup>H and <sup>l3</sup>C nuclear magnetic resonance (NMR), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR) and magnetic measurements. In order to study the pharmacokinetic profile of the compounds, ADMET analysis was performed. The in vitro studies revealed that the synthesized compounds exhibit potent biological activity against A549 human cancer cell line.https://www.mdpi.com/1420-3049/27/9/2703thiosemicarbazidesmetal complexesA549 cancer cellsantitumor activitybiological activitythermogravimetric analysis |
| spellingShingle | Bartłomiej Rogalewicz Alina Climova Ekaterina Pivovarova Jarosław Sukiennik Kamila Czarnecka Paweł Szymański Małgorzata Szczesio Katarzyna Gas Maciej Sawicki Monika Pitucha Agnieszka Czylkowska Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes Molecules thiosemicarbazides metal complexes A549 cancer cells antitumor activity biological activity thermogravimetric analysis |
| title | Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes |
| title_full | Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes |
| title_fullStr | Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes |
| title_full_unstemmed | Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes |
| title_short | Antitumor Activity and Physicochemical Properties of New Thiosemicarbazide Derivative and Its Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) Complexes |
| title_sort | antitumor activity and physicochemical properties of new thiosemicarbazide derivative and its co ii ni ii cu ii zn ii and cd ii complexes |
| topic | thiosemicarbazides metal complexes A549 cancer cells antitumor activity biological activity thermogravimetric analysis |
| url | https://www.mdpi.com/1420-3049/27/9/2703 |
| work_keys_str_mv | AT bartłomiejrogalewicz antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT alinaclimova antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT ekaterinapivovarova antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT jarosławsukiennik antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT kamilaczarnecka antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT pawełszymanski antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT małgorzataszczesio antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT katarzynagas antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT maciejsawicki antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT monikapitucha antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes AT agnieszkaczylkowska antitumoractivityandphysicochemicalpropertiesofnewthiosemicarbazidederivativeanditscoiiniiicuiizniiandcdiicomplexes |