Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer
The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong imp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01830/full |
| _version_ | 1819094330602684416 |
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| author | Veronica Lazar Veronica Lazar Lia-Mara Ditu Lia-Mara Ditu Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Irina Gheorghe Irina Gheorghe Carmen Curutiu Carmen Curutiu Alina Maria Holban Alina Maria Holban Ariana Picu Ariana Picu Laura Petcu Laura Petcu Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc |
| author_facet | Veronica Lazar Veronica Lazar Lia-Mara Ditu Lia-Mara Ditu Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Irina Gheorghe Irina Gheorghe Carmen Curutiu Carmen Curutiu Alina Maria Holban Alina Maria Holban Ariana Picu Ariana Picu Laura Petcu Laura Petcu Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc |
| author_sort | Veronica Lazar |
| collection | DOAJ |
| description | The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed. |
| first_indexed | 2024-12-21T23:25:42Z |
| format | Article |
| id | doaj.art-ac7e53c49eff45bcbe7b8e1513b9594c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T23:25:42Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ac7e53c49eff45bcbe7b8e1513b9594c2022-12-21T18:46:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-08-01910.3389/fimmu.2018.01830354337Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and CancerVeronica Lazar0Veronica Lazar1Lia-Mara Ditu2Lia-Mara Ditu3Gratiela Gradisteanu Pircalabioru4Gratiela Gradisteanu Pircalabioru5Irina Gheorghe6Irina Gheorghe7Carmen Curutiu8Carmen Curutiu9Alina Maria Holban10Alina Maria Holban11Ariana Picu12Ariana Picu13Laura Petcu14Laura Petcu15Mariana Carmen Chifiriuc16Mariana Carmen Chifiriuc17Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaNational Institute for Diabetes, Nutrition and Metabolic Diseases Prof. Dr. N. Paulescu, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaNational Institute for Diabetes, Nutrition and Metabolic Diseases Prof. Dr. N. Paulescu, Bucharest, RomaniaDepartment of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Bucharest, RomaniaEarth, Environmental and Life Sciences Section, Research Institute of the University of Bucharest, Bucharest, RomaniaThe microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.https://www.frontiersin.org/article/10.3389/fimmu.2018.01830/fullgut microbiotaopportunistic infectionsautoimmunitychronic inflammationcancerantibiotics |
| spellingShingle | Veronica Lazar Veronica Lazar Lia-Mara Ditu Lia-Mara Ditu Gratiela Gradisteanu Pircalabioru Gratiela Gradisteanu Pircalabioru Irina Gheorghe Irina Gheorghe Carmen Curutiu Carmen Curutiu Alina Maria Holban Alina Maria Holban Ariana Picu Ariana Picu Laura Petcu Laura Petcu Mariana Carmen Chifiriuc Mariana Carmen Chifiriuc Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer Frontiers in Immunology gut microbiota opportunistic infections autoimmunity chronic inflammation cancer antibiotics |
| title | Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer |
| title_full | Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer |
| title_fullStr | Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer |
| title_full_unstemmed | Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer |
| title_short | Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer |
| title_sort | aspects of gut microbiota and immune system interactions in infectious diseases immunopathology and cancer |
| topic | gut microbiota opportunistic infections autoimmunity chronic inflammation cancer antibiotics |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01830/full |
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