Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial
Background: The current pandemic of Coronavirus disease 2019 (COVID-19) and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. Objective: The present study aimed to evaluate the effect of Iranian traditional pol...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2022-03-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-3193-en.html |
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| author | Hasan Fallah Huseini Mohammadreza Gholibeikian Majid Shohrati Afsaneh Kaffash Ali Taheri Hojatolah Khajepour Mehdi Raei Saeed Kianbakht Amena Fallah Hosseini Majid Ghorbani Nohooji Reza Mohtashami |
| author_facet | Hasan Fallah Huseini Mohammadreza Gholibeikian Majid Shohrati Afsaneh Kaffash Ali Taheri Hojatolah Khajepour Mehdi Raei Saeed Kianbakht Amena Fallah Hosseini Majid Ghorbani Nohooji Reza Mohtashami |
| author_sort | Hasan Fallah Huseini |
| collection | DOAJ |
| description | Background: The current pandemic of Coronavirus disease 2019 (COVID-19) and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. Objective: The present study aimed to evaluate the effect of Iranian traditional polyherbal medicine (Imfluna) containing a mixture of echinacea, stachys, artemisia, hyssopus, polybody, alpinia, ginger, and ginseng extract on symptoms of COVID-19 infected patients. Methods: In this placebocontrolled and double-blind clinical trial, a total of 60 voluntarily approved patients with COVID-19 were randomly assigned to the placebo and Imfluna groups. Patients in each group, in addition to receiving standard medications, took two 500 mg capsules of Imflona or placebo every 8 hours for 2 weeks. The patient's vital signs, including the severity of shortness of breath, cough, and body temperature, were recorded during the study. Also blood ESR, liver and kidney function tests were performed at baseline and endpoint. Results: The results showed that patients in the Imfluna-treated group had significantly greater improvement in daily cough, shortness of breath and ESR compared with the placebo group. In addition, lung lesions improved in the Imfluna-treated group, although not significantly. Conclusion: Patients with COVID-19 who were treated with Imfluna for 2 weeks had better comfort and fewer symptoms associated with the disease with no any drug side effects. |
| first_indexed | 2024-12-10T08:34:55Z |
| format | Article |
| id | doaj.art-ac7e5f85b33344acacaf7e62f51f6616 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-10T08:34:55Z |
| publishDate | 2022-03-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-ac7e5f85b33344acacaf7e62f51f66162022-12-22T01:56:00ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582022-03-0121815166Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trialHasan Fallah Huseini0Mohammadreza Gholibeikian1Majid Shohrati2Afsaneh Kaffash3Ali Taheri4Hojatolah Khajepour5Mehdi Raei6Saeed Kianbakht7Amena Fallah Hosseini8Majid Ghorbani Nohooji9Reza Mohtashami10 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran Department of Pharmacotherapy, Faculty of Pharmacy, Baqiyatallah Uiversity of Medical Sciences, Tehran, Iran Department of Internal Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzavar, Iran Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Medicine Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Background: The current pandemic of Coronavirus disease 2019 (COVID-19) and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. Objective: The present study aimed to evaluate the effect of Iranian traditional polyherbal medicine (Imfluna) containing a mixture of echinacea, stachys, artemisia, hyssopus, polybody, alpinia, ginger, and ginseng extract on symptoms of COVID-19 infected patients. Methods: In this placebocontrolled and double-blind clinical trial, a total of 60 voluntarily approved patients with COVID-19 were randomly assigned to the placebo and Imfluna groups. Patients in each group, in addition to receiving standard medications, took two 500 mg capsules of Imflona or placebo every 8 hours for 2 weeks. The patient's vital signs, including the severity of shortness of breath, cough, and body temperature, were recorded during the study. Also blood ESR, liver and kidney function tests were performed at baseline and endpoint. Results: The results showed that patients in the Imfluna-treated group had significantly greater improvement in daily cough, shortness of breath and ESR compared with the placebo group. In addition, lung lesions improved in the Imfluna-treated group, although not significantly. Conclusion: Patients with COVID-19 who were treated with Imfluna for 2 weeks had better comfort and fewer symptoms associated with the disease with no any drug side effects.http://jmp.ir/article-1-3193-en.htmlclinical trialcovid-19polyherbal medicineiranian traditionalmedicineimfluna |
| spellingShingle | Hasan Fallah Huseini Mohammadreza Gholibeikian Majid Shohrati Afsaneh Kaffash Ali Taheri Hojatolah Khajepour Mehdi Raei Saeed Kianbakht Amena Fallah Hosseini Majid Ghorbani Nohooji Reza Mohtashami Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial Journal of Medicinal Plants clinical trial covid-19 polyherbal medicine iranian traditional medicine imfluna |
| title | Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial |
| title_full | Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial |
| title_fullStr | Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial |
| title_full_unstemmed | Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial |
| title_short | Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial |
| title_sort | effects of imfluna an iranian traditional polyherbal medicine on covid 19 symptoms a randomized double blind and placebo controlled clinical trial |
| topic | clinical trial covid-19 polyherbal medicine iranian traditional medicine imfluna |
| url | http://jmp.ir/article-1-3193-en.html |
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