Structural insights into how augmin augments the mitotic spindle
Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al. describe consistent integrated atomic models of the extraordinarily fl...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37625-3 |
| _version_ | 1797845893186060288 |
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| author | Szymon W. Manka |
| author_facet | Szymon W. Manka |
| author_sort | Szymon W. Manka |
| collection | DOAJ |
| description | Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al. describe consistent integrated atomic models of the extraordinarily flexible augmin complex. Their work prompts the question: what is this flexibility really needed for? |
| first_indexed | 2024-04-09T17:46:21Z |
| format | Article |
| id | doaj.art-ac7f056450d2493d823e2c20650a61b8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T17:46:21Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ac7f056450d2493d823e2c20650a61b82023-04-16T11:18:51ZengNature PortfolioNature Communications2041-17232023-04-011411310.1038/s41467-023-37625-3Structural insights into how augmin augments the mitotic spindleSzymon W. Manka0MRC Prion Unit at UCL, Institute of Prion Diseases, University College LondonCell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al. describe consistent integrated atomic models of the extraordinarily flexible augmin complex. Their work prompts the question: what is this flexibility really needed for?https://doi.org/10.1038/s41467-023-37625-3 |
| spellingShingle | Szymon W. Manka Structural insights into how augmin augments the mitotic spindle Nature Communications |
| title | Structural insights into how augmin augments the mitotic spindle |
| title_full | Structural insights into how augmin augments the mitotic spindle |
| title_fullStr | Structural insights into how augmin augments the mitotic spindle |
| title_full_unstemmed | Structural insights into how augmin augments the mitotic spindle |
| title_short | Structural insights into how augmin augments the mitotic spindle |
| title_sort | structural insights into how augmin augments the mitotic spindle |
| url | https://doi.org/10.1038/s41467-023-37625-3 |
| work_keys_str_mv | AT szymonwmanka structuralinsightsintohowaugminaugmentsthemitoticspindle |