The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review
Eustathios Kenanidis,1,2 Panagiotis Kakoulidis,1,2 Dimitrios Karponis,3 Eleftherios Tsiridis1,2 1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Thessaloniki, Greece; 2Center of Orthopaedic and Regenerative Medicine - Center of Interdisciplinary R...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-09-01
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| Series: | Patient Related Outcome Measures |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-effect-of-perioperative-vitamin-d-levels-on-the-functional-patient-peer-reviewed-article-PROM |
| _version_ | 1818133525927297024 |
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| author | Kenanidis E Kakoulidis P Karponis D Tsiridis E |
| author_facet | Kenanidis E Kakoulidis P Karponis D Tsiridis E |
| author_sort | Kenanidis E |
| collection | DOAJ |
| description | Eustathios Kenanidis,1,2 Panagiotis Kakoulidis,1,2 Dimitrios Karponis,3 Eleftherios Tsiridis1,2 1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Thessaloniki, Greece; 2Center of Orthopaedic and Regenerative Medicine - Center of Interdisciplinary Research and Innovation, Aristotle University Medical School, Thessaloniki, Greece; 3Oxford University Clinical Academic Graduate School, University of Oxford, Oxford, UKCorrespondence: Eustathios KenanidisConsultant Orthopaedic Surgeon, Pontou 25, Panorama 55236, Thessaloniki, GreeceTel +30 6973693693Email stathiskenanidis@gmail.comIntroduction: The aim of this study was to evaluate the effect of perioperative vitamin D levels in terms of functional results, patient-related outcome measures (PROMs) and infection risk after hip or knee replacement.Materials and Methods: A systematic search in PubMed, Cochrane library, ScienceDirect and ClinicalTrials.gov was conducted according to the PRISMA guidelines from inception to January 2020.Results: Eighteen studies with more than 8000 knee and 1500 hip joint arthroplasties were included. The mean follow-up ranged from 6 weeks to 1 year and mean patients’ age from 59.4 to 76 years. Hypovitaminosis was diagnosed in 26.7% of cases. Most studies did not find significant differences in pre- and postoperative functional results, PROMs and length of hospital stay between hypovitaminosis and euvitaminosis groups. Deficient patients may be at higher risk of postoperative joint stiffness. Patients suffering from hip and knee periprosthetic joint infection seem to have lower vitamin D levels compared to those with aseptic loosening of implants.Conclusion: The necessity of pre-operative correction of vitamin D levels to achieve better functional results and minimize the risk of infection following hip and knee arthroplasty remains inconclusive. Extend of exposure to low vitamin D levels and comparison between outliers needs further evaluation.Keywords: vitamin D, hip arthroplasty, THA, knee arthroplasty, TKA |
| first_indexed | 2024-12-11T08:54:07Z |
| format | Article |
| id | doaj.art-ac7f4fec7fd04f228d3de62fe63fe719 |
| institution | Directory Open Access Journal |
| issn | 1179-271X |
| language | English |
| last_indexed | 2024-12-11T08:54:07Z |
| publishDate | 2020-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Related Outcome Measures |
| spelling | doaj.art-ac7f4fec7fd04f228d3de62fe63fe7192022-12-22T01:13:56ZengDove Medical PressPatient Related Outcome Measures1179-271X2020-09-01Volume 1116117156841The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic ReviewKenanidis EKakoulidis PKarponis DTsiridis EEustathios Kenanidis,1,2 Panagiotis Kakoulidis,1,2 Dimitrios Karponis,3 Eleftherios Tsiridis1,2 1Academic Orthopaedic Department, Papageorgiou General Hospital, Aristotle University Medical School, Thessaloniki, Greece; 2Center of Orthopaedic and Regenerative Medicine - Center of Interdisciplinary Research and Innovation, Aristotle University Medical School, Thessaloniki, Greece; 3Oxford University Clinical Academic Graduate School, University of Oxford, Oxford, UKCorrespondence: Eustathios KenanidisConsultant Orthopaedic Surgeon, Pontou 25, Panorama 55236, Thessaloniki, GreeceTel +30 6973693693Email stathiskenanidis@gmail.comIntroduction: The aim of this study was to evaluate the effect of perioperative vitamin D levels in terms of functional results, patient-related outcome measures (PROMs) and infection risk after hip or knee replacement.Materials and Methods: A systematic search in PubMed, Cochrane library, ScienceDirect and ClinicalTrials.gov was conducted according to the PRISMA guidelines from inception to January 2020.Results: Eighteen studies with more than 8000 knee and 1500 hip joint arthroplasties were included. The mean follow-up ranged from 6 weeks to 1 year and mean patients’ age from 59.4 to 76 years. Hypovitaminosis was diagnosed in 26.7% of cases. Most studies did not find significant differences in pre- and postoperative functional results, PROMs and length of hospital stay between hypovitaminosis and euvitaminosis groups. Deficient patients may be at higher risk of postoperative joint stiffness. Patients suffering from hip and knee periprosthetic joint infection seem to have lower vitamin D levels compared to those with aseptic loosening of implants.Conclusion: The necessity of pre-operative correction of vitamin D levels to achieve better functional results and minimize the risk of infection following hip and knee arthroplasty remains inconclusive. Extend of exposure to low vitamin D levels and comparison between outliers needs further evaluation.Keywords: vitamin D, hip arthroplasty, THA, knee arthroplasty, TKAhttps://www.dovepress.com/the-effect-of-perioperative-vitamin-d-levels-on-the-functional-patient-peer-reviewed-article-PROMvitamin dhip arthroplastythaknee arthroplastytka |
| spellingShingle | Kenanidis E Kakoulidis P Karponis D Tsiridis E The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review Patient Related Outcome Measures vitamin d hip arthroplasty tha knee arthroplasty tka |
| title | The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review |
| title_full | The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review |
| title_fullStr | The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review |
| title_full_unstemmed | The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review |
| title_short | The Effect of Perioperative Vitamin D Levels on the Functional, Patient-Related Outcome Measures and the Risk of Infection Following Hip and Knee Arthroplasty: A Systematic Review |
| title_sort | effect of perioperative vitamin d levels on the functional patient related outcome measures and the risk of infection following hip and knee arthroplasty a systematic review |
| topic | vitamin d hip arthroplasty tha knee arthroplasty tka |
| url | https://www.dovepress.com/the-effect-of-perioperative-vitamin-d-levels-on-the-functional-patient-peer-reviewed-article-PROM |
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