An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study
Interest has arisen on the anti-inflammatory action of dietary components, including long-chain n-3 fatty acids (LCn3) and polyphenols (PP). The aim of this study was to evaluate the effects of diets rich in PP and oily fish (high-LCn3 diets) on markers of subclinical inflammation and growth factors...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/11/3369 |
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| author | Giuseppina Costabile Giuseppe Della Pepa Claudia Vetrani Paola Vitaglione Ettore Griffo Rosalba Giacco Marilena Vitale Dominic Salamone Angela Albarosa Rivellese Giovanni Annuzzi Lutgarda Bozzetto |
| author_facet | Giuseppina Costabile Giuseppe Della Pepa Claudia Vetrani Paola Vitaglione Ettore Griffo Rosalba Giacco Marilena Vitale Dominic Salamone Angela Albarosa Rivellese Giovanni Annuzzi Lutgarda Bozzetto |
| author_sort | Giuseppina Costabile |
| collection | DOAJ |
| description | Interest has arisen on the anti-inflammatory action of dietary components, including long-chain n-3 fatty acids (LCn3) and polyphenols (PP). The aim of this study was to evaluate the effects of diets rich in PP and oily fish (high-LCn3 diets) on markers of subclinical inflammation and growth factors in people at high cardiometabolic risk. Individuals with high waist circumference and one more component of metabolic syndrome were randomized to one of the following isoenergetic diets: low LCn3&PP, high LCn3, high PP, high LCn3&PP. Before and after 8 weeks, fasting and postprandial plasma concentrations of hs-CRP and fasting serum concentrations of IL-1, IL-4, IL-6, IL-10, IL-17, INF-, TNF-, FGF, VEGF, PDGF-, G-CSF, and GM-CSF were determined. An oily fish diet reduced fasting plasma hs-CRP (1.28 ± 12.0, −12.5 ± 6.9, 22.5 ± 33.6, −12.2 ± 11.9; 8-week percent change, Mean ± SEM; low LCn3&PP, high LCn3, high PP, high LCn3&PP group, respectively), postprandial 6h-AUC hs-CRP (4.6 ± 16.3, −18.2 ± 7.2, 26.9 ± 35.1, −11.5 ± 11.8, 8-week percent change) and fasting IL-6 (20.8 ± 18.7, −2.44 ± 12.4, 28.1 ± 17.4, −9.6 ± 10.2), IL-17 (2.40 ± 4.9, −13.3 ± 4.9, 3.8 ± 4.43, −11.5 ± 4.7), and VEGF (−5.7 ± 5.8, −5.6 ± 7.5, 3.5 ± 5.8, −11.1 ± 5.5) (8-week percent change; <i>p</i> < 0.05 for LCn3 effect for all; no significant effect for PP; 2-factor ANOVA). An oily fish diet improved subclinical inflammation, while no significant effect was observed for dietary polyphenols. |
| first_indexed | 2024-03-10T10:46:09Z |
| format | Article |
| id | doaj.art-ac7fa4983aa64bbd90108193366394de |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:46:09Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ac7fa4983aa64bbd90108193366394de2023-11-21T22:35:46ZengMDPI AGMolecules1420-30492021-06-012611336910.3390/molecules26113369An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled StudyGiuseppina Costabile0Giuseppe Della Pepa1Claudia Vetrani2Paola Vitaglione3Ettore Griffo4Rosalba Giacco5Marilena Vitale6Dominic Salamone7Angela Albarosa Rivellese8Giovanni Annuzzi9Lutgarda Bozzetto10Department of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Agricultural Sciences, Federico II University, 80055 Portici, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyInstitute of Food Sciences, National Research Council, 83100 Avellino, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyDepartment of Clinical Medicine and Surgery, Federico II University, 80130 Naples, ItalyInterest has arisen on the anti-inflammatory action of dietary components, including long-chain n-3 fatty acids (LCn3) and polyphenols (PP). The aim of this study was to evaluate the effects of diets rich in PP and oily fish (high-LCn3 diets) on markers of subclinical inflammation and growth factors in people at high cardiometabolic risk. Individuals with high waist circumference and one more component of metabolic syndrome were randomized to one of the following isoenergetic diets: low LCn3&PP, high LCn3, high PP, high LCn3&PP. Before and after 8 weeks, fasting and postprandial plasma concentrations of hs-CRP and fasting serum concentrations of IL-1, IL-4, IL-6, IL-10, IL-17, INF-, TNF-, FGF, VEGF, PDGF-, G-CSF, and GM-CSF were determined. An oily fish diet reduced fasting plasma hs-CRP (1.28 ± 12.0, −12.5 ± 6.9, 22.5 ± 33.6, −12.2 ± 11.9; 8-week percent change, Mean ± SEM; low LCn3&PP, high LCn3, high PP, high LCn3&PP group, respectively), postprandial 6h-AUC hs-CRP (4.6 ± 16.3, −18.2 ± 7.2, 26.9 ± 35.1, −11.5 ± 11.8, 8-week percent change) and fasting IL-6 (20.8 ± 18.7, −2.44 ± 12.4, 28.1 ± 17.4, −9.6 ± 10.2), IL-17 (2.40 ± 4.9, −13.3 ± 4.9, 3.8 ± 4.43, −11.5 ± 4.7), and VEGF (−5.7 ± 5.8, −5.6 ± 7.5, 3.5 ± 5.8, −11.1 ± 5.5) (8-week percent change; <i>p</i> < 0.05 for LCn3 effect for all; no significant effect for PP; 2-factor ANOVA). An oily fish diet improved subclinical inflammation, while no significant effect was observed for dietary polyphenols.https://www.mdpi.com/1420-3049/26/11/3369inflammationC-reactive proteininterleukinsdietpolyphenolsn-3 fatty acids |
| spellingShingle | Giuseppina Costabile Giuseppe Della Pepa Claudia Vetrani Paola Vitaglione Ettore Griffo Rosalba Giacco Marilena Vitale Dominic Salamone Angela Albarosa Rivellese Giovanni Annuzzi Lutgarda Bozzetto An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study Molecules inflammation C-reactive protein interleukins diet polyphenols n-3 fatty acids |
| title | An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study |
| title_full | An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study |
| title_fullStr | An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study |
| title_full_unstemmed | An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study |
| title_short | An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study |
| title_sort | oily fish diet improves subclinical inflammation in people at high cardiovascular risk a randomized controlled study |
| topic | inflammation C-reactive protein interleukins diet polyphenols n-3 fatty acids |
| url | https://www.mdpi.com/1420-3049/26/11/3369 |
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