Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis
Abstract Background: Although several studies have evaluated the risk of gynecological cancers in women with polycystic ovary syndrome (PCOS), there are controversies regarding it. Objective: This study aimed to investigate the association of PCOS with endometrial, ovarian, and breast cancers. Mater...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2022-11-01
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| Series: | International Journal of Reproductive BioMedicine |
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| Online Access: | https://doi.org/10.18502/ijrm.v20i11.12357 |
| _version_ | 1797975202256125952 |
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| author | Mina Amiri Razieh Bidhendi-Yarandi Aida Fallahzadeh Zahra Marzban Fahimeh Ramezani Tehrani |
| author_facet | Mina Amiri Razieh Bidhendi-Yarandi Aida Fallahzadeh Zahra Marzban Fahimeh Ramezani Tehrani |
| author_sort | Mina Amiri |
| collection | DOAJ |
| description | Abstract Background: Although several studies have evaluated the risk of gynecological cancers in women with polycystic ovary syndrome (PCOS), there are controversies regarding it. Objective: This study aimed to investigate the association of PCOS with endometrial, ovarian, and breast cancers. Materials and Methods: PubMed, Scopus, Web of Science, and Google Scholar databases based on MESH terms using the combination of the appropriate keywords were searched to retrieve observational studies on endometrial, ovarian, and breast cancers in PCOS women, published from inception to April 2020. This meta-analysis was performed to determine the pooled odds ratio (OR) of these cancers in women with PCOS. Publication bias was assessed by using Begg's test. Results: Of 1347 records retrieved by searching the databases, a total of 14 articles were included in the study. Overall, the pooled OR of the composite outcome, including endometrial, ovarian, and breast cancers in women with PCOS was higher than that of women with no PCOS (pooled OR: 1.4, 95% CI: 1.0-1.9). The pooled OR of endometrial (pooled OR: 2.2, 95% CI: 1.03-4.7) and ovarian (pooled OR: 1.3, 95% CI: 1.0-1.8) cancers in women with PCOS was higher than the control group, whereas the pooled OR of breast cancer was not significantly higher than that of the control group. Conclusion: This meta-analysis indicated an increased risk of endometrial and ovarian cancers in women with PCOS. |
| first_indexed | 2024-04-11T04:31:46Z |
| format | Article |
| id | doaj.art-ac809a7b1f6d488b8e0ae4d075ac8bf8 |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-04-11T04:31:46Z |
| publishDate | 2022-11-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-ac809a7b1f6d488b8e0ae4d075ac8bf82022-12-29T05:59:24ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722022-11-01201189391410.18502/ijrm.v20i11.12357ijrm.v20i11.12357Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysisMina Amiri0Razieh Bidhendi-Yarandi1Aida Fallahzadeh2Zahra Marzban3Fahimeh Ramezani Tehrani4 Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Abstract Background: Although several studies have evaluated the risk of gynecological cancers in women with polycystic ovary syndrome (PCOS), there are controversies regarding it. Objective: This study aimed to investigate the association of PCOS with endometrial, ovarian, and breast cancers. Materials and Methods: PubMed, Scopus, Web of Science, and Google Scholar databases based on MESH terms using the combination of the appropriate keywords were searched to retrieve observational studies on endometrial, ovarian, and breast cancers in PCOS women, published from inception to April 2020. This meta-analysis was performed to determine the pooled odds ratio (OR) of these cancers in women with PCOS. Publication bias was assessed by using Begg's test. Results: Of 1347 records retrieved by searching the databases, a total of 14 articles were included in the study. Overall, the pooled OR of the composite outcome, including endometrial, ovarian, and breast cancers in women with PCOS was higher than that of women with no PCOS (pooled OR: 1.4, 95% CI: 1.0-1.9). The pooled OR of endometrial (pooled OR: 2.2, 95% CI: 1.03-4.7) and ovarian (pooled OR: 1.3, 95% CI: 1.0-1.8) cancers in women with PCOS was higher than the control group, whereas the pooled OR of breast cancer was not significantly higher than that of the control group. Conclusion: This meta-analysis indicated an increased risk of endometrial and ovarian cancers in women with PCOS.https://doi.org/10.18502/ijrm.v20i11.12357polycystic ovary syndrome, endometrial cancer, ovarian cancer, breast cancer. |
| spellingShingle | Mina Amiri Razieh Bidhendi-Yarandi Aida Fallahzadeh Zahra Marzban Fahimeh Ramezani Tehrani Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis International Journal of Reproductive BioMedicine polycystic ovary syndrome, endometrial cancer, ovarian cancer, breast cancer. |
| title | Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_full | Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_fullStr | Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_full_unstemmed | Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_short | Risk of endometrial, ovarian, and breast cancers in women with polycystic ovary syndrome: A systematic review and meta-analysis |
| title_sort | risk of endometrial ovarian and breast cancers in women with polycystic ovary syndrome a systematic review and meta analysis |
| topic | polycystic ovary syndrome, endometrial cancer, ovarian cancer, breast cancer. |
| url | https://doi.org/10.18502/ijrm.v20i11.12357 |
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