LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS
In a relatively short period of time new coronavirus disease (COVID-19) has become a global threat, both to human health and to the functioning of human society in general. This pandemic is certainly neither the first nor is it likely to be the last disease episode in human history. At the moment,...
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| Format: | Article |
| Language: | English |
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University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2020-12-01
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| Series: | Genetics & Applications |
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| Online Access: | https://genapp.ba/editions/index.php/journal/article/view/117 |
| _version_ | 1828289436209643520 |
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| author | Damir Marjanović Dragan Primorac Vid Matišić Vitorio Perić Vilim Molnar Renata Zadro |
| author_facet | Damir Marjanović Dragan Primorac Vid Matišić Vitorio Perić Vilim Molnar Renata Zadro |
| author_sort | Damir Marjanović |
| collection | DOAJ |
| description |
In a relatively short period of time new coronavirus disease (COVID-19) has become a global threat, both to human health and to the functioning of human society in general. This pandemic is certainly neither the first nor is it likely to be the last disease episode in human history. At the moment, it is still too early to make a reliable assessment of its total effect on human civilization, but it can already be stated that this disease, and its causative agent SARS-CoV-2 virus, have caused a strong scientific response all around the World. For the first time in this magnitude, it has united the resources of large scientific institutions and companies with the aim of finding solutions for fast and accurate virus detection procedures, effective and safe vaccine, reliable medical treatments, etc. It is astonishing that only a month has passed from the first officially detected case to the complete sequencing of the SARS-CoV-2 virus genome and the creation of the first detection systems based on RT-PCR method. After that, numerous scientific teams and companies worked together, or independently, to improve the detection methods. Their work included further optimization of PCR and other genetic approaches, as well as the development of detection methods based on the analysis of specific antibodies and viral antigens. The aim of this paper is to review the results that were achieved in this area so far, analyze the strategies currently used in the world and the region, and to predict future steps in the process of optimizing and improving methods for SARS CoV-2 detection in individual patients and the global human population.
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| first_indexed | 2024-04-13T10:20:59Z |
| format | Article |
| id | doaj.art-ac80f79b7f3f4abcbbe48303c5861c71 |
| institution | Directory Open Access Journal |
| issn | 2566-2937 2566-431X |
| language | English |
| last_indexed | 2024-04-13T10:20:59Z |
| publishDate | 2020-12-01 |
| publisher | University of Sarajevo, Institute for Genetic Engineering and Biotechnology |
| record_format | Article |
| series | Genetics & Applications |
| spelling | doaj.art-ac80f79b7f3f4abcbbe48303c5861c712022-12-22T02:50:29ZengUniversity of Sarajevo, Institute for Genetic Engineering and BiotechnologyGenetics & Applications2566-29372566-431X2020-12-014210.31383/ga.vol4iss2pp1-9LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODSDamir Marjanović0Dragan Primorac1Vid Matišić2Vitorio Perić3Vilim Molnar4Renata Zadro5International Burch University, Sarajevo, Bosnia and HerzegovinaUniversity of Split, School of Medicine, 21000 Split, CroatiaSt. Catherine Specialty Hospital, 49210 Zabok/ 10000 Zagreb, CroatiaSt. Catherine Specialty Hospital, 49210 Zabok/ 10000 Zagreb, CroatiaSt. Catherine Specialty Hospital, 49210 Zabok/ 10000 Zagreb, CroatiaSt. Catherine Specialty Hospital, 49210 Zabok/ 10000 Zagreb, Croatia In a relatively short period of time new coronavirus disease (COVID-19) has become a global threat, both to human health and to the functioning of human society in general. This pandemic is certainly neither the first nor is it likely to be the last disease episode in human history. At the moment, it is still too early to make a reliable assessment of its total effect on human civilization, but it can already be stated that this disease, and its causative agent SARS-CoV-2 virus, have caused a strong scientific response all around the World. For the first time in this magnitude, it has united the resources of large scientific institutions and companies with the aim of finding solutions for fast and accurate virus detection procedures, effective and safe vaccine, reliable medical treatments, etc. It is astonishing that only a month has passed from the first officially detected case to the complete sequencing of the SARS-CoV-2 virus genome and the creation of the first detection systems based on RT-PCR method. After that, numerous scientific teams and companies worked together, or independently, to improve the detection methods. Their work included further optimization of PCR and other genetic approaches, as well as the development of detection methods based on the analysis of specific antibodies and viral antigens. The aim of this paper is to review the results that were achieved in this area so far, analyze the strategies currently used in the world and the region, and to predict future steps in the process of optimizing and improving methods for SARS CoV-2 detection in individual patients and the global human population. https://genapp.ba/editions/index.php/journal/article/view/117SARS-CoV-2RT-PCRantigenantibodytesting |
| spellingShingle | Damir Marjanović Dragan Primorac Vid Matišić Vitorio Perić Vilim Molnar Renata Zadro LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS Genetics & Applications SARS-CoV-2 RT-PCR antigen antibody testing |
| title | LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS |
| title_full | LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS |
| title_fullStr | LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS |
| title_full_unstemmed | LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS |
| title_short | LABORATORY TESTING AND SCREENING FOR SARS-CoV-2: A REVIEW OF CURRENT METHODS |
| title_sort | laboratory testing and screening for sars cov 2 a review of current methods |
| topic | SARS-CoV-2 RT-PCR antigen antibody testing |
| url | https://genapp.ba/editions/index.php/journal/article/view/117 |
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