Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach
This study on a breast cancer survivor suffering from cancer-related fatigue (CaRF) and depression investigated the bidirectional relationship between cellular immune activity and subjective sleep. The 49-year-old patient (breast cancer diagnosis 5 years before the study, currently in remission) col...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fneur.2017.00693/full |
| _version_ | 1828484950939140096 |
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| author | Magdalena Singer Magdalena Singer Christina Burbaum Kurt Fritzsche Sylvia Peterlini Harald R. Bliem Francisco M. Ocaña-Peinado Dietmar Fuchs Christian Schubert |
| author_facet | Magdalena Singer Magdalena Singer Christina Burbaum Kurt Fritzsche Sylvia Peterlini Harald R. Bliem Francisco M. Ocaña-Peinado Dietmar Fuchs Christian Schubert |
| author_sort | Magdalena Singer |
| collection | DOAJ |
| description | This study on a breast cancer survivor suffering from cancer-related fatigue (CaRF) and depression investigated the bidirectional relationship between cellular immune activity and subjective sleep. The 49-year-old patient (breast cancer diagnosis 5 years before the study, currently in remission) collected her full urine output for 28 days in 12-h intervals (8:00 p.m. to 8:00 a.m. and 8:00 a.m. to 8:00 p.m.). These urine samples were used to determine urinary neopterin (cellular immune activation marker) and creatinine concentrations via high-pressure liquid chromatography (HPLC). Each morning, the patient answered questions on five sleep variables: sleep quality (SQ), sleep recreational value (SRV), total sleep time (TST), total wake time (TWT), and awakenings during sleep period (ADS). For the purpose of this study, the time series of the nighttime urinary neopterin levels and the five sleep variables were determined. Using centered moving average (CMA) smoothing and cross-correlational analysis, this study showed that increases in the positive sleep variables SQ and SRV were followed by urinary neopterin concentration decreases after 96–120 h (SQ, lag 4: r = −0.411; p = 0.044; SRV: lag 4: r = −0.472; p = 0.021) and 120–144 h (SRV, lag 5: r = −0.464; p = 0.026). Increases in the negative sleep variable TWT, by contrast, were followed by increases in urinary neopterin concentrations 72–96 h later (lag 3: r = 0.522; p = 0.009). No systematic effects in the other direction, i.e., from urinary neopterin levels to sleep, were observed in this study. Although preliminary, the findings of this study highlight the benefit of carefully investigating temporal delays and directions of effects when studying the dynamic relationship between sleep and immune variables in the natural context of everyday life. |
| first_indexed | 2024-12-11T09:04:44Z |
| format | Article |
| id | doaj.art-ac82a56d585b4fc1857d79c3e8ab837c |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T09:04:44Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-ac82a56d585b4fc1857d79c3e8ab837c2022-12-22T01:13:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-01-01810.3389/fneur.2017.00693301643Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis ApproachMagdalena Singer0Magdalena Singer1Christina Burbaum2Kurt Fritzsche3Sylvia Peterlini4Harald R. Bliem5Francisco M. Ocaña-Peinado6Dietmar Fuchs7Christian Schubert8Clinical Department of Medical Psychology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Psychology, University Innsbruck, Innsbruck, AustriaDepartment of Rehabilitation Psychology and Psychotherapy, University of Freiburg, Freiburg, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Freiburg, Freiburg, GermanyClinical Department of Medical Psychology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Psychology, University Innsbruck, Innsbruck, AustriaDepartment of Statistics and Operations Research, University of Granada, Granada, SpainDivision of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, AustriaClinical Department of Medical Psychology, Medical University of Innsbruck, Innsbruck, AustriaThis study on a breast cancer survivor suffering from cancer-related fatigue (CaRF) and depression investigated the bidirectional relationship between cellular immune activity and subjective sleep. The 49-year-old patient (breast cancer diagnosis 5 years before the study, currently in remission) collected her full urine output for 28 days in 12-h intervals (8:00 p.m. to 8:00 a.m. and 8:00 a.m. to 8:00 p.m.). These urine samples were used to determine urinary neopterin (cellular immune activation marker) and creatinine concentrations via high-pressure liquid chromatography (HPLC). Each morning, the patient answered questions on five sleep variables: sleep quality (SQ), sleep recreational value (SRV), total sleep time (TST), total wake time (TWT), and awakenings during sleep period (ADS). For the purpose of this study, the time series of the nighttime urinary neopterin levels and the five sleep variables were determined. Using centered moving average (CMA) smoothing and cross-correlational analysis, this study showed that increases in the positive sleep variables SQ and SRV were followed by urinary neopterin concentration decreases after 96–120 h (SQ, lag 4: r = −0.411; p = 0.044; SRV: lag 4: r = −0.472; p = 0.021) and 120–144 h (SRV, lag 5: r = −0.464; p = 0.026). Increases in the negative sleep variable TWT, by contrast, were followed by increases in urinary neopterin concentrations 72–96 h later (lag 3: r = 0.522; p = 0.009). No systematic effects in the other direction, i.e., from urinary neopterin levels to sleep, were observed in this study. Although preliminary, the findings of this study highlight the benefit of carefully investigating temporal delays and directions of effects when studying the dynamic relationship between sleep and immune variables in the natural context of everyday life.http://journal.frontiersin.org/article/10.3389/fneur.2017.00693/fullcancersleepneopterintime-series analysissingle-case design |
| spellingShingle | Magdalena Singer Magdalena Singer Christina Burbaum Kurt Fritzsche Sylvia Peterlini Harald R. Bliem Francisco M. Ocaña-Peinado Dietmar Fuchs Christian Schubert Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach Frontiers in Neurology cancer sleep neopterin time-series analysis single-case design |
| title | Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach |
| title_full | Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach |
| title_fullStr | Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach |
| title_full_unstemmed | Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach |
| title_short | Subjective Positive and Negative Sleep Variables Differentially Affect Cellular Immune Activity in a Breast Cancer Survivor: A Time-series Analysis Approach |
| title_sort | subjective positive and negative sleep variables differentially affect cellular immune activity in a breast cancer survivor a time series analysis approach |
| topic | cancer sleep neopterin time-series analysis single-case design |
| url | http://journal.frontiersin.org/article/10.3389/fneur.2017.00693/full |
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