Dexamethasone and potassium canrenoate alleviate hyperalgesia by competitively regulating IL‐6/JAK2/STAT3 signaling pathway during inflammatory pain in vivo and in vitro

Dexamethasone and potassium canrenoate alleviate hyperalgesia by competitively regulating IL‐6/JAK2/STAT3 signaling pathway during inflammatory pain in vivo and in vitro

Abstract Background Dexamethasone (Dexa) and potassium canrenoate (Cane) modulate nociceptive behavior via glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) by two mechanisms (genomic and nongenomic pathways). This study was designed to investigate the Dexa‐ or Cane‐mediated nongenomi...

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Bibliographic Details
Main Authors: Jie Liu, Xiaolan Xie, Kai Qin, Le Xu, Juxiang Peng, Xiangyu Li, Xiongjuan Li, Zhiheng Liu
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Immunity, Inflammation and Disease
Subjects:
dexamethasone
IL‐6
inflammatory pain
potassium canrenoate
Online Access:https://doi.org/10.1002/iid3.721

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