STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART
In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin mo...
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2017-03-01
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| Series: | Research Results in Pharmacology |
| Subjects: | |
| Online Access: | https://rrpharmacology.pensoft.net/article/31044/download/pdf/ |
| _version_ | 1797431031516626944 |
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| author | Oleg Kesarev Lyudmila Danilenko Mikhail Pokrovskii Alena Alena Anatolii Khavanskii |
| author_facet | Oleg Kesarev Lyudmila Danilenko Mikhail Pokrovskii Alena Alena Anatolii Khavanskii |
| author_sort | Oleg Kesarev |
| collection | DOAJ |
| description | In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high heart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate. The results indicate that Mexicor at the dose of 21.43 mg/kg/day does not provide a cardioprotective effect in this model of pathology. Mexicor has the cardioprotective effect at the dose of 85.72 mg/kg/day in relation to the isolated heart, that is resulted in the recovery of the contractile function of the heart and reducing the "diastole defect" (SТТI). |
| first_indexed | 2024-03-09T09:37:05Z |
| format | Article |
| id | doaj.art-ac847dc593904ed7bb38f18258faf61b |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:37:05Z |
| publishDate | 2017-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-ac847dc593904ed7bb38f18258faf61b2023-12-02T01:41:18ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2017-03-01313910.18413/2500-235X-2017-3-1-3-931044STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEARTOleg KesarevLyudmila DanilenkoMikhail PokrovskiiAlena AlenaAnatolii KhavanskiiIn experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high heart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate. The results indicate that Mexicor at the dose of 21.43 mg/kg/day does not provide a cardioprotective effect in this model of pathology. Mexicor has the cardioprotective effect at the dose of 85.72 mg/kg/day in relation to the isolated heart, that is resulted in the recovery of the contractile function of the heart and reducing the "diastole defect" (SТТI).https://rrpharmacology.pensoft.net/article/31044/download/pdf/2-ethyl-6-methyl-3 hydroxypyridine succinatedoxo |
| spellingShingle | Oleg Kesarev Lyudmila Danilenko Mikhail Pokrovskii Alena Alena Anatolii Khavanskii STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART Research Results in Pharmacology 2-ethyl-6-methyl-3 hydroxypyridine succinate doxo |
| title | STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART |
| title_full | STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART |
| title_fullStr | STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART |
| title_full_unstemmed | STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART |
| title_short | STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART |
| title_sort | study of dose dependent effect of 2 ethyl 6 methyl 3 hydroxypyridine succinate on the contractile function of isolated rat heart |
| topic | 2-ethyl-6-methyl-3 hydroxypyridine succinate doxo |
| url | https://rrpharmacology.pensoft.net/article/31044/download/pdf/ |
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