Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders
Abstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients w...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00582-1 |
| _version_ | 1818856500470218752 |
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| author | Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares |
| author_facet | Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares |
| author_sort | Bo Cao |
| collection | DOAJ |
| description | Abstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients. |
| first_indexed | 2024-12-19T08:25:29Z |
| format | Article |
| id | doaj.art-ac84c0b7eea64d51b9fe56f7d27ad75a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T08:25:29Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ac84c0b7eea64d51b9fe56f7d27ad75a2022-12-21T20:29:18ZengNature PortfolioScientific Reports2045-23222017-03-01711810.1038/s41598-017-00582-1Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric DisordersBo Cao0Benson Mwangi1Ives Cavalcante Passos2Mon-Ju Wu3Zafer Keser4Giovana B. Zunta-Soares5Dianping Xu6Khader M. Hasan7Jair C. Soares8Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonGraduation Program in Psychiatry and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do SulDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonDepartment of Neurology, The University of Texas Science Center at HoustonDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonDepartment of Diagnostic and Interventional Imaging, The University of Texas Science Center at HoustonDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at HoustonAbstract Cortical gyrification of the brain represents the folding characteristic of the cerebral cortex. How the brain cortical gyrification changes from childhood to old age in healthy human subjects is still unclear. Additionally, studies have shown regional gyrification alterations in patients with major psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). However, whether the lifespan trajectory of gyrification over the brain is altered in patients diagnosed with major psychiatric disorders is still unknown. In this study, we investigated the trajectories of gyrification in three independent cohorts based on structural brain images of 881 subjects from age 4 to 83. We discovered that the trajectory of gyrification during normal development and aging was not linear and could be modeled with a logarithmic function. We also found that the gyrification trajectories of patients with MDD, BD and SCZ were deviated from the healthy one during adulthood, indicating altered aging in the brain of these patients.https://doi.org/10.1038/s41598-017-00582-1 |
| spellingShingle | Bo Cao Benson Mwangi Ives Cavalcante Passos Mon-Ju Wu Zafer Keser Giovana B. Zunta-Soares Dianping Xu Khader M. Hasan Jair C. Soares Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders Scientific Reports |
| title | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders |
| title_full | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders |
| title_fullStr | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders |
| title_full_unstemmed | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders |
| title_short | Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders |
| title_sort | lifespan gyrification trajectories of human brain in healthy individuals and patients with major psychiatric disorders |
| url | https://doi.org/10.1038/s41598-017-00582-1 |
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