Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming?
Objective: to evaluate changes in the biochemical profile of children treated or being treated for moderate or severe stunting in a nutrition recovery and education center. Methods: this was a retrospective longitudinal study of 263 children treated at this center between August of 2008 to August of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Portuguese |
| Published: |
Brazilian Society of Pediatrics
2014-07-01
|
| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553614000743 |
| _version_ | 1828159517168238592 |
|---|---|
| author | Jullyana F.R. Alves Revilane P.A. Britto Haroldo S. Ferreira Ana L. Sawaya Telma M.M.T. Florêncio |
| author_facet | Jullyana F.R. Alves Revilane P.A. Britto Haroldo S. Ferreira Ana L. Sawaya Telma M.M.T. Florêncio |
| author_sort | Jullyana F.R. Alves |
| collection | DOAJ |
| description | Objective: to evaluate changes in the biochemical profile of children treated or being treated for moderate or severe stunting in a nutrition recovery and education center.
Methods: this was a retrospective longitudinal study of 263 children treated at this center between August of 2008 to August of 2011, aged 1 to 6 years, diagnosed with moderate (z‐score of height‐for‐age [HAZ] < −2) or severe stunting (HAZ < −3). Data were collected on socioeconomic conditions, dietary habits, and biochemical changes, as well as height according to age.
Results: the nutritional intervention showed an increase in HAZ of children with moderate (0.51 ± 0.4, p = 0.001) and severe (0.91 ± 0.7, p = 0.001) stunting during the monitoring. Increased levels of insulin‐like growth factor 1 (IGF‐1) (initial: 71.7 ng/dL; final: 90.4 ng/dL; p = 0.01) were also observed, as well as a reduction in triglycerides (TG) in both severely (initial: 91.8 mg/dL; final: 79.1 mg/dL; p = 0.01) and in moderately malnourished children (initial: 109.2 mg/dL; final 88.7 mg/dL; p = 0.01), and a significant increase in high‐density lipoprotein cholesterol HDL‐C only in the third year of intervention (initial: 31.4 mg/dL; final: 42.2 mg/dL). The values of total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels remained high throughout the treatment (initial: 165.1 mg/dL; final: 163.5 mg/dL and initial: 109.0 mg/dL; final: 107.3 mg/dL, respectively).
Conclusion: the nutritional treatment for children with short stature was effective in reducing stunting and improving TG and HDL‐C after three years of intervention. However, the levels of LDL‐C and TC remained high even in treated children. It is therefore speculated that these changes may result from metabolic programming due to malnutrition. |
| first_indexed | 2024-04-12T00:02:06Z |
| format | Article |
| id | doaj.art-ac856531bdda4a8fb66c9b261a9cb20c |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:02:06Z |
| publishDate | 2014-07-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-ac856531bdda4a8fb66c9b261a9cb20c2022-12-22T03:56:13ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362014-07-0190435636210.1016/j.jpedp.2013.12.006Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming?Jullyana F.R. Alves0Revilane P.A. Britto1Haroldo S. Ferreira2Ana L. Sawaya3Telma M.M.T. Florêncio4Escola de Nutrição, Universidade Federal de Alagoas (UFAL), Maceió, AL, BrasilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilEscola de Nutrição, Universidade Federal de Alagoas (UFAL), Maceió, AL, BrasilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, BrasilEscola de Nutrição, Universidade Federal de Alagoas (UFAL), Maceió, AL, BrasilObjective: to evaluate changes in the biochemical profile of children treated or being treated for moderate or severe stunting in a nutrition recovery and education center. Methods: this was a retrospective longitudinal study of 263 children treated at this center between August of 2008 to August of 2011, aged 1 to 6 years, diagnosed with moderate (z‐score of height‐for‐age [HAZ] < −2) or severe stunting (HAZ < −3). Data were collected on socioeconomic conditions, dietary habits, and biochemical changes, as well as height according to age. Results: the nutritional intervention showed an increase in HAZ of children with moderate (0.51 ± 0.4, p = 0.001) and severe (0.91 ± 0.7, p = 0.001) stunting during the monitoring. Increased levels of insulin‐like growth factor 1 (IGF‐1) (initial: 71.7 ng/dL; final: 90.4 ng/dL; p = 0.01) were also observed, as well as a reduction in triglycerides (TG) in both severely (initial: 91.8 mg/dL; final: 79.1 mg/dL; p = 0.01) and in moderately malnourished children (initial: 109.2 mg/dL; final 88.7 mg/dL; p = 0.01), and a significant increase in high‐density lipoprotein cholesterol HDL‐C only in the third year of intervention (initial: 31.4 mg/dL; final: 42.2 mg/dL). The values of total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels remained high throughout the treatment (initial: 165.1 mg/dL; final: 163.5 mg/dL and initial: 109.0 mg/dL; final: 107.3 mg/dL, respectively). Conclusion: the nutritional treatment for children with short stature was effective in reducing stunting and improving TG and HDL‐C after three years of intervention. However, the levels of LDL‐C and TC remained high even in treated children. It is therefore speculated that these changes may result from metabolic programming due to malnutrition.http://www.sciencedirect.com/science/article/pii/S2255553614000743StuntingDyslipidemiaInsulin growth factor‐like IMetabolic diseasesNutritional recovery |
| spellingShingle | Jullyana F.R. Alves Revilane P.A. Britto Haroldo S. Ferreira Ana L. Sawaya Telma M.M.T. Florêncio Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? Jornal de Pediatria (Versão em Português) Stunting Dyslipidemia Insulin growth factor‐like I Metabolic diseases Nutritional recovery |
| title | Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? |
| title_full | Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? |
| title_fullStr | Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? |
| title_full_unstemmed | Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? |
| title_short | Evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting: consequences of metabolic programming? |
| title_sort | evolution of the biochemical profile of children treated or undergoing treatment for moderate or severe stunting consequences of metabolic programming |
| topic | Stunting Dyslipidemia Insulin growth factor‐like I Metabolic diseases Nutritional recovery |
| url | http://www.sciencedirect.com/science/article/pii/S2255553614000743 |
| work_keys_str_mv | AT jullyanafralves evolutionofthebiochemicalprofileofchildrentreatedorundergoingtreatmentformoderateorseverestuntingconsequencesofmetabolicprogramming AT revilanepabritto evolutionofthebiochemicalprofileofchildrentreatedorundergoingtreatmentformoderateorseverestuntingconsequencesofmetabolicprogramming AT haroldosferreira evolutionofthebiochemicalprofileofchildrentreatedorundergoingtreatmentformoderateorseverestuntingconsequencesofmetabolicprogramming AT analsawaya evolutionofthebiochemicalprofileofchildrentreatedorundergoingtreatmentformoderateorseverestuntingconsequencesofmetabolicprogramming AT telmammtflorencio evolutionofthebiochemicalprofileofchildrentreatedorundergoingtreatmentformoderateorseverestuntingconsequencesofmetabolicprogramming |