Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor
In recent years, various approaches to the prodrug design on the basis of anti-HIV active nucleoside compounds used in the therapy are intensively investigated. In this paper, the principles of modifying this class of drugs by lipid substances allowing obtained conjugates to insert in natural lipid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2011-04-01
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| Series: | Тонкие химические технологии |
| Subjects: | |
| Online Access: | https://www.finechem-mirea.ru/jour/article/view/866 |
| _version_ | 1826565861707612160 |
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| author | N. S. Shastina E. O. Baranova L. N. Dyakova D. V. Lonshakov V. I. Shvets |
| author_facet | N. S. Shastina E. O. Baranova L. N. Dyakova D. V. Lonshakov V. I. Shvets |
| author_sort | N. S. Shastina |
| collection | DOAJ |
| description | In recent years, various approaches to the prodrug design on the basis of anti-HIV active nucleoside compounds used in the therapy are intensively investigated. In this paper, the principles of modifying this class of drugs by lipid substances allowing obtained conjugates to insert in natural lipid transport and metabolic pathways that can increase nucleoside agents bioavailability are described. Literature data associated with the research of the pronucleotide approach serving the purpose of increasing nucleoside drugs therapeutical efficacy and reducing the side effects on the organism are reviewed. Experimental data obtained by the authors in course of research of synthetic routes and properties of the new lipid-modified anti-HIV nucleosides are also presented. |
| first_indexed | 2024-04-10T03:31:09Z |
| format | Article |
| id | doaj.art-ac85836972ba4a5d858616a5573c3964 |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2025-03-14T10:42:29Z |
| publishDate | 2011-04-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-ac85836972ba4a5d858616a5573c39642025-03-02T10:57:27ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752011-04-01627180860Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitorN. S. Shastina0E. O. Baranova1L. N. Dyakova2D. V. Lonshakov3V. I. Shvets4МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86In recent years, various approaches to the prodrug design on the basis of anti-HIV active nucleoside compounds used in the therapy are intensively investigated. In this paper, the principles of modifying this class of drugs by lipid substances allowing obtained conjugates to insert in natural lipid transport and metabolic pathways that can increase nucleoside agents bioavailability are described. Literature data associated with the research of the pronucleotide approach serving the purpose of increasing nucleoside drugs therapeutical efficacy and reducing the side effects on the organism are reviewed. Experimental data obtained by the authors in course of research of synthetic routes and properties of the new lipid-modified anti-HIV nucleosides are also presented.https://www.finechem-mirea.ru/jour/article/view/866anti-hiv-nucleosidesprodrugspseudo triglyceridesinositol containing phospholipidsbioavailability |
| spellingShingle | N. S. Shastina E. O. Baranova L. N. Dyakova D. V. Lonshakov V. I. Shvets Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor Тонкие химические технологии anti-hiv-nucleosides prodrugs pseudo triglycerides inositol containing phospholipids bioavailability |
| title | Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor |
| title_full | Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor |
| title_fullStr | Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor |
| title_full_unstemmed | Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor |
| title_short | Lipidic strategy for improving bioavailability of nucleoside HIV reverse transcriptase inhibitor |
| title_sort | lipidic strategy for improving bioavailability of nucleoside hiv reverse transcriptase inhibitor |
| topic | anti-hiv-nucleosides prodrugs pseudo triglycerides inositol containing phospholipids bioavailability |
| url | https://www.finechem-mirea.ru/jour/article/view/866 |
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