Familial hypercholesterolemia in Southeast and East Asia
Familial hypercholesterolemia (FH) is a relatively common autosomal dominant disorder associated with a significantly increased risk of coronary heart disease (CHD). Most (~85–90%) cases are due to pathogenic variants in the LDL-receptor gene (LDLR), while the remaining are due to pathogenic variant...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | American Journal of Preventive Cardiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266666772100012X |
| _version_ | 1818661765273092096 |
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| author | Candace L. Jackson Magdi Zordok Iftikhar J. Kullo |
| author_facet | Candace L. Jackson Magdi Zordok Iftikhar J. Kullo |
| author_sort | Candace L. Jackson |
| collection | DOAJ |
| description | Familial hypercholesterolemia (FH) is a relatively common autosomal dominant disorder associated with a significantly increased risk of coronary heart disease (CHD). Most (~85–90%) cases are due to pathogenic variants in the LDL-receptor gene (LDLR), while the remaining are due to pathogenic variants in the apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes, though the proportion may vary depending on geographic location. Even though at least a quarter of the world's FH population lives in Southeast and East Asia, there are substantial gaps in knowledge regarding the epidemiology of FH due to low awareness, the absence of national screening programs, and limited availability of genetic testing. In this review, we discuss the most recent and relevant information available related to diagnostic criteria, prevalence, awareness, clinical characteristics, genetic epidemiology, and treatment in the FH population of Southeast and East Asia. Increasing awareness and improving the diagnosis and management of FH will reduce the burden of premature CHD in these regions of the world. |
| first_indexed | 2024-12-17T04:50:15Z |
| format | Article |
| id | doaj.art-ac86b7f790a845deab7da4956804836f |
| institution | Directory Open Access Journal |
| issn | 2666-6677 |
| language | English |
| last_indexed | 2024-12-17T04:50:15Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj.art-ac86b7f790a845deab7da4956804836f2022-12-21T22:02:55ZengElsevierAmerican Journal of Preventive Cardiology2666-66772021-06-016100157Familial hypercholesterolemia in Southeast and East AsiaCandace L. Jackson0Magdi Zordok1Iftikhar J. Kullo2Department of Medicine, Mayo Clinic, Rochester, MN USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN USA; Corresponding author.Familial hypercholesterolemia (FH) is a relatively common autosomal dominant disorder associated with a significantly increased risk of coronary heart disease (CHD). Most (~85–90%) cases are due to pathogenic variants in the LDL-receptor gene (LDLR), while the remaining are due to pathogenic variants in the apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes, though the proportion may vary depending on geographic location. Even though at least a quarter of the world's FH population lives in Southeast and East Asia, there are substantial gaps in knowledge regarding the epidemiology of FH due to low awareness, the absence of national screening programs, and limited availability of genetic testing. In this review, we discuss the most recent and relevant information available related to diagnostic criteria, prevalence, awareness, clinical characteristics, genetic epidemiology, and treatment in the FH population of Southeast and East Asia. Increasing awareness and improving the diagnosis and management of FH will reduce the burden of premature CHD in these regions of the world.http://www.sciencedirect.com/science/article/pii/S266666772100012XFamilial hypercholesterolemiaSoutheast AsiaEast AsiaGenetic testingAwarenessPrevalence |
| spellingShingle | Candace L. Jackson Magdi Zordok Iftikhar J. Kullo Familial hypercholesterolemia in Southeast and East Asia American Journal of Preventive Cardiology Familial hypercholesterolemia Southeast Asia East Asia Genetic testing Awareness Prevalence |
| title | Familial hypercholesterolemia in Southeast and East Asia |
| title_full | Familial hypercholesterolemia in Southeast and East Asia |
| title_fullStr | Familial hypercholesterolemia in Southeast and East Asia |
| title_full_unstemmed | Familial hypercholesterolemia in Southeast and East Asia |
| title_short | Familial hypercholesterolemia in Southeast and East Asia |
| title_sort | familial hypercholesterolemia in southeast and east asia |
| topic | Familial hypercholesterolemia Southeast Asia East Asia Genetic testing Awareness Prevalence |
| url | http://www.sciencedirect.com/science/article/pii/S266666772100012X |
| work_keys_str_mv | AT candaceljackson familialhypercholesterolemiainsoutheastandeastasia AT magdizordok familialhypercholesterolemiainsoutheastandeastasia AT iftikharjkullo familialhypercholesterolemiainsoutheastandeastasia |