In vivo18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation

In vivo18F-DOPA PET imaging identifies a dopaminergic deficit in a rat model with a G51D α-synuclein mutation

Parkinson’s disease (PD) is a neurodegenerative condition with several major hallmarks, including loss of substantia nigra neurons, reduction in striatal dopaminergic function, and formation of α-synuclein-rich Lewy bodies. Mutations in SNCA, encoding for α-synuclein, are a known cause of familial P...

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Bibliographic Details
Main Authors: Victoria Morley, Karamjit Singh Dolt, Carlos J. Alcaide-Corral, Tashfeen Walton, Christophe Lucatelli, Tomoji Mashimo, Adriana A. S. Tavares, Tilo Kunath
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson’s
G51D α-synuclein mutation
rat model
PET imaging
kinetic modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1095761/full

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