Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague–Dawley rats

Cross-talk between ER stress and mitochondrial pathway mediated adriamycin-induced testicular toxicity and DA-9401 modulate adriamycin-induced apoptosis in Sprague–Dawley rats

Abstract Background DA-9401 was prepared as a mixture of Chinese medicinal herb extracts from roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliceae) and seeds of Cuscuta chinensis Lamark (Convolvulaceae). The present study was designed to investigate the possible pro...

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Bibliographic Details
Main Authors: Keshab Kumar Karna, Bo Ram Choi, Jae Hyung You, Yu Seob Shin, Kiran Kumar Soni, Wan Shou Cui, Sung Won Lee, Chul Young Kim, Hye Kyung Kim, Jong Kwan Park
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
DA-9401
Adriamycin (ADR)
Endoplasmic reticulum (ER) stress
Oxidative stress
Apoptosis
Steroidogenic acute regulatory protein (StAR)
Online Access:http://link.springer.com/article/10.1186/s12935-019-0805-2

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