A role for Hes1 in constraining germinal center B cell formation
Germinal center is a transient lymphoid tissue structure in which B cells undergo affinity maturation and differentiate into memory B cells and plasma cells. GC formation depends on B cell expression of BCL6, a master transcription regulator of the GC state. Bcl6 expression is under elaborate contro...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Cell Insight |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892723000020 |
| _version_ | 1811166418696142848 |
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| author | Xingxing Shao Xin Liu Hai Qi |
| author_facet | Xingxing Shao Xin Liu Hai Qi |
| author_sort | Xingxing Shao |
| collection | DOAJ |
| description | Germinal center is a transient lymphoid tissue structure in which B cells undergo affinity maturation and differentiate into memory B cells and plasma cells. GC formation depends on B cell expression of BCL6, a master transcription regulator of the GC state. Bcl6 expression is under elaborate control by external signals. HES1 plays important roles in T-cell lineage commitment, although little is known about its potential roles in GC formation. Here we report that B-cell-specific HES1 deletion causes a significant increase in GC formation, leading to increased production of plasma cells. We further provide evidence that HES1 inhibits BCL6 expression in a bHLH domain-dependent manner. Our study suggests a new layer of regulation of GC initiation mediated by HES1 and, by inference, Notch signals in vivo. |
| first_indexed | 2024-04-10T15:52:02Z |
| format | Article |
| id | doaj.art-ac88b8ef350a42c4a96d09ed3d2be830 |
| institution | Directory Open Access Journal |
| issn | 2772-8927 |
| language | English |
| last_indexed | 2024-04-10T15:52:02Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj.art-ac88b8ef350a42c4a96d09ed3d2be8302023-02-11T04:16:47ZengElsevierCell Insight2772-89272023-04-0122100078A role for Hes1 in constraining germinal center B cell formationXingxing Shao0Xin Liu1Hai Qi2Tsinghua-Peking Center for Life Sciences, Beijing, China; Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China; School of Life Sciences, Tsinghua University, Beijing, ChinaLaboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, ChinaTsinghua-Peking Center for Life Sciences, Beijing, China; Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China; School of Life Sciences, Tsinghua University, Beijing, China; Department of Basic Medical Sciences, School of Medicine, Tsinghua University, Beijing, China; Frontiers Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China; Corresponding author. Tsinghua-Peking Center for Life Sciences, Beijing, China.Germinal center is a transient lymphoid tissue structure in which B cells undergo affinity maturation and differentiate into memory B cells and plasma cells. GC formation depends on B cell expression of BCL6, a master transcription regulator of the GC state. Bcl6 expression is under elaborate control by external signals. HES1 plays important roles in T-cell lineage commitment, although little is known about its potential roles in GC formation. Here we report that B-cell-specific HES1 deletion causes a significant increase in GC formation, leading to increased production of plasma cells. We further provide evidence that HES1 inhibits BCL6 expression in a bHLH domain-dependent manner. Our study suggests a new layer of regulation of GC initiation mediated by HES1 and, by inference, Notch signals in vivo.http://www.sciencedirect.com/science/article/pii/S2772892723000020 |
| spellingShingle | Xingxing Shao Xin Liu Hai Qi A role for Hes1 in constraining germinal center B cell formation Cell Insight |
| title | A role for Hes1 in constraining germinal center B cell formation |
| title_full | A role for Hes1 in constraining germinal center B cell formation |
| title_fullStr | A role for Hes1 in constraining germinal center B cell formation |
| title_full_unstemmed | A role for Hes1 in constraining germinal center B cell formation |
| title_short | A role for Hes1 in constraining germinal center B cell formation |
| title_sort | role for hes1 in constraining germinal center b cell formation |
| url | http://www.sciencedirect.com/science/article/pii/S2772892723000020 |
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