Intelligent Hydrogels in Myocardial Regeneration and Engineering

Myocardial infarction (MI) causes impaired cardiac function due to the loss of cardiomyocytes following an ischemic attack. Intelligent hydrogels offer promising solutions for post-MI cardiac tissue therapy to aid in structural support, contractility, and targeted drug therapy. Hydrogels are porous...

Full description

Bibliographic Details
Main Authors: Christian Doescher, An Thai, Ed Cha, Pauline V. Cheng, Devendra K. Agrawal, Finosh G. Thankam
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Gels
Subjects:
Online Access:https://www.mdpi.com/2310-2861/8/9/576
Description
Summary:Myocardial infarction (MI) causes impaired cardiac function due to the loss of cardiomyocytes following an ischemic attack. Intelligent hydrogels offer promising solutions for post-MI cardiac tissue therapy to aid in structural support, contractility, and targeted drug therapy. Hydrogels are porous hydrophilic matrices used for biological scaffolding, and upon the careful alteration of ideal functional groups, the hydrogels respond to the chemistry of the surrounding microenvironment, resulting in intelligent hydrogels. This review delves into the perspectives of various intelligent hydrogels and evidence from successful models of hydrogel-assisted treatment strategies.
ISSN:2310-2861