Loss of <i>parla</i> Function Results in Inactivity, Olfactory Impairment, and Dopamine Neuron Loss in Zebrafish

Loss of <i>parla</i> Function Results in Inactivity, Olfactory Impairment, and Dopamine Neuron Loss in Zebrafish

The presenilin-associated rhomboid-like (<i>PARL</i>) gene was found to contribute to mitochondrial morphology and function and was linked to familial Parkinson’s disease (PD). The <i>PARL</i> gene product is a mitochondrial intramembrane cleaving protease that acts on a numb...

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Bibliographic Details
Main Authors: Rawan Merhi, Michael Kalyn, Amanda Zhu-Pawlowsky, Marc Ekker
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomedicines
Subjects:
Parkinson’s disease
<i>parla</i>
dopaminergic neurons
mitochondria
gene expression
locomotor
Online Access:https://www.mdpi.com/2227-9059/9/2/205

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