Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage
Liver damage can lead to secondary organ damage by toxic substances and catabolic products accumulation which can increase the permeability of blood-brain barrier, leading to cognitive impairment. The only real treatment for end stage liver failure is grafting. With some, but not all, neurological s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/12/1622 |
| _version_ | 1797506463684362240 |
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| author | Shandiz Morega Bogdan Cătălin Cristiana Eugenia Simionescu Konstantinos Sapalidis Ion Rogoveanu |
| author_facet | Shandiz Morega Bogdan Cătălin Cristiana Eugenia Simionescu Konstantinos Sapalidis Ion Rogoveanu |
| author_sort | Shandiz Morega |
| collection | DOAJ |
| description | Liver damage can lead to secondary organ damage by toxic substances and catabolic products accumulation which can increase the permeability of blood-brain barrier, leading to cognitive impairment. The only real treatment for end stage liver failure is grafting. With some, but not all, neurological symptoms subsiding after transplantation, the presence of brain damage can impair both the short and long-term outcome. We tested if Cerebrolysin can prevent brain injury in an experimental model of non-viral liver damage in mice. Behavior, abdominal ultrasound evaluation and immunohistochemistry were used to evaluate the animals. No ultrasound or behavior differences were found between the control and treated animals, with both groups displaying more anxiety and no short-term memory benefit compared to sham mice. Cerebrolysin treatment was able to maintain a normal level of cortical NeuN<sup>+</sup> cells and induced an increase in the area occupied by BrdU<sup>+</sup> cells. Surprisingly, no difference was observed when investigating Iba1<sup>+</sup> cells. With neurological complications of end-stage liver disease impacting the rehabilitation of patients receiving liver grafts, a neuroprotective treatment of patients on the waiting lists might improve their rehabilitation outcome by ensuring a minimal cerebral damage. |
| first_indexed | 2024-03-10T04:33:01Z |
| format | Article |
| id | doaj.art-ac8a9bbbf6474f1abdde5b92273abd80 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T04:33:01Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ac8a9bbbf6474f1abdde5b92273abd802023-11-23T04:02:14ZengMDPI AGBrain Sciences2076-34252021-12-011112162210.3390/brainsci11121622Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver DamageShandiz Morega0Bogdan Cătălin1Cristiana Eugenia Simionescu2Konstantinos Sapalidis3Ion Rogoveanu4U.M.F. Doctoral School Craiova, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaExperimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaDepartment of Pathology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania3rd Department of Surgery, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceGastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaLiver damage can lead to secondary organ damage by toxic substances and catabolic products accumulation which can increase the permeability of blood-brain barrier, leading to cognitive impairment. The only real treatment for end stage liver failure is grafting. With some, but not all, neurological symptoms subsiding after transplantation, the presence of brain damage can impair both the short and long-term outcome. We tested if Cerebrolysin can prevent brain injury in an experimental model of non-viral liver damage in mice. Behavior, abdominal ultrasound evaluation and immunohistochemistry were used to evaluate the animals. No ultrasound or behavior differences were found between the control and treated animals, with both groups displaying more anxiety and no short-term memory benefit compared to sham mice. Cerebrolysin treatment was able to maintain a normal level of cortical NeuN<sup>+</sup> cells and induced an increase in the area occupied by BrdU<sup>+</sup> cells. Surprisingly, no difference was observed when investigating Iba1<sup>+</sup> cells. With neurological complications of end-stage liver disease impacting the rehabilitation of patients receiving liver grafts, a neuroprotective treatment of patients on the waiting lists might improve their rehabilitation outcome by ensuring a minimal cerebral damage.https://www.mdpi.com/2076-3425/11/12/1622liver transplantationneurological complicationsneuroprotection |
| spellingShingle | Shandiz Morega Bogdan Cătălin Cristiana Eugenia Simionescu Konstantinos Sapalidis Ion Rogoveanu Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage Brain Sciences liver transplantation neurological complications neuroprotection |
| title | Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage |
| title_full | Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage |
| title_fullStr | Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage |
| title_full_unstemmed | Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage |
| title_short | Cerebrolysin Prevents Brain Injury in a Mouse Model of Liver Damage |
| title_sort | cerebrolysin prevents brain injury in a mouse model of liver damage |
| topic | liver transplantation neurological complications neuroprotection |
| url | https://www.mdpi.com/2076-3425/11/12/1622 |
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