Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression
Background/Aims: Astrocytes are critical for the development of postoperative cognitive dysfunction (POCD). In addition, astrocytes express toll-like receptors 4 (TLR4) and build up responses to innate immune triggers by releasing pro-inflammatory molecules. The pathogenesis of neurological disorder...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2016-02-01
|
| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/443028 |
| _version_ | 1811277336547426304 |
|---|---|
| author | Nana Li Xiang Zhang Hongquan Dong Susu Zhang Jie Sun Yanning Qian |
| author_facet | Nana Li Xiang Zhang Hongquan Dong Susu Zhang Jie Sun Yanning Qian |
| author_sort | Nana Li |
| collection | DOAJ |
| description | Background/Aims: Astrocytes are critical for the development of postoperative cognitive dysfunction (POCD). In addition, astrocytes express toll-like receptors 4 (TLR4) and build up responses to innate immune triggers by releasing pro-inflammatory molecules. The pathogenesis of neurological disorders often involves the activation of astrocytes and associated inflammatory processes. Lithium, a primary drug for the treatment of bipolar disorder, has recently been suggested to have a role in neuroprotection during neurodegenerative diseases. In this study, we aimed to investigate whether lithium can ameliorate LPS-induced astrocytes activation via inhibition of TLR4 expression. Methods: Primary astrocytes cells were pretreated with lithium and stimulated with lipopolysaccharide (LPS). Cellular activation, cytokine production, and TLR4 expression, were assessed. Results: Lithium significantly inhibited LPS-induced astrocytes activation and pro-inflammatory cytokine production, as well as LPS-induced TLR4 expression. Conclusions: Lithium can inhibit LPS-induced TLR4 expression and astrocytes activation. These results indicate that lithium plays an important role in astrocytes activation and neuroinflammation-related diseases, which may open new avenues for neuroscience and biomedical research, and also offers new insight into the treatment of POCD. |
| first_indexed | 2024-04-13T00:15:04Z |
| format | Article |
| id | doaj.art-ac8d72b6288042d38474c9bd888b2ef7 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-04-13T00:15:04Z |
| publishDate | 2016-02-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-ac8d72b6288042d38474c9bd888b2ef72022-12-22T03:10:59ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782016-02-0138271472510.1159/000443028443028Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 ExpressionNana LiXiang ZhangHongquan DongSusu ZhangJie SunYanning QianBackground/Aims: Astrocytes are critical for the development of postoperative cognitive dysfunction (POCD). In addition, astrocytes express toll-like receptors 4 (TLR4) and build up responses to innate immune triggers by releasing pro-inflammatory molecules. The pathogenesis of neurological disorders often involves the activation of astrocytes and associated inflammatory processes. Lithium, a primary drug for the treatment of bipolar disorder, has recently been suggested to have a role in neuroprotection during neurodegenerative diseases. In this study, we aimed to investigate whether lithium can ameliorate LPS-induced astrocytes activation via inhibition of TLR4 expression. Methods: Primary astrocytes cells were pretreated with lithium and stimulated with lipopolysaccharide (LPS). Cellular activation, cytokine production, and TLR4 expression, were assessed. Results: Lithium significantly inhibited LPS-induced astrocytes activation and pro-inflammatory cytokine production, as well as LPS-induced TLR4 expression. Conclusions: Lithium can inhibit LPS-induced TLR4 expression and astrocytes activation. These results indicate that lithium plays an important role in astrocytes activation and neuroinflammation-related diseases, which may open new avenues for neuroscience and biomedical research, and also offers new insight into the treatment of POCD.http://www.karger.com/Article/FullText/443028POCDAstrocytesLithiumTLR4 |
| spellingShingle | Nana Li Xiang Zhang Hongquan Dong Susu Zhang Jie Sun Yanning Qian Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression Cellular Physiology and Biochemistry POCD Astrocytes Lithium TLR4 |
| title | Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression |
| title_full | Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression |
| title_fullStr | Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression |
| title_full_unstemmed | Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression |
| title_short | Lithium Ameliorates LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression |
| title_sort | lithium ameliorates lps induced astrocytes activation partly via inhibition of toll like receptor 4 expression |
| topic | POCD Astrocytes Lithium TLR4 |
| url | http://www.karger.com/Article/FullText/443028 |
| work_keys_str_mv | AT nanali lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression AT xiangzhang lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression AT hongquandong lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression AT susuzhang lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression AT jiesun lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression AT yanningqian lithiumameliorateslpsinducedastrocytesactivationpartlyviainhibitionoftolllikereceptor4expression |