Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells

Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells

Abstract Background Lubricin, a proteoglycan encoded by the PRG4 gene, is synthesised by superficial zone (SFZ) chondrocytes and synovial cells. It reduces friction between joints and allows smooth sliding of tendons. Although lubricin has been shown to be effective against osteoarthritis and synovi...

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Bibliographic Details
Main Authors: Takashi Satake, Shingo Komura, Hitomi Aoki, Akihiro Hirakawa, Yuuki Imai, Haruhiko Akiyama
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Molecular and Cell Biology
Subjects:
iPSCs
Prg4
Superficial zone chondrocytes
Fibroblast-like synovial cells
Online Access:https://doi.org/10.1186/s12860-022-00431-8

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