miR-653-5p suppresses the viability and migration of fibroblast-like synoviocytes by targeting FGF2 and inactivation of the Wnt/beta-catenin pathway

miR-653-5p suppresses the viability and migration of fibroblast-like synoviocytes by targeting FGF2 and inactivation of the Wnt/beta-catenin pathway

Abstract Background Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Several studies reported that fibroblast-like synoviocytes (FLSs) and miRNAs are associated with RA pathogenesis. This study explored the function of miR-653-5p in the regulation of human fibroblast-like synovioc...

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Bibliographic Details
Main Authors: Peilong Dong, Xiaobo Tang, Jian Wang, Botao Zhu, Zhiyun Li
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
miR-653-5p
FGF2
Rheumatoid arthritis
Fibroblast-like synoviocytes
Online Access:https://doi.org/10.1186/s13018-021-02887-4

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