Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis
Osteoarthritis (OA) is the most common type of arthritis and chronic joint disease, affecting more than 240 million people worldwide. Although there are numerous advances in using drugs in treating OA, the use of natural compounds has aroused much interest among researchers due to their safety margi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/9/1722 |
| _version_ | 1827664002357919744 |
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| author | Yi Ting Lee Mohd Heikal Mohd Yunus Azizah Ugusman Muhammad Dain Yazid |
| author_facet | Yi Ting Lee Mohd Heikal Mohd Yunus Azizah Ugusman Muhammad Dain Yazid |
| author_sort | Yi Ting Lee |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common type of arthritis and chronic joint disease, affecting more than 240 million people worldwide. Although there are numerous advances in using drugs in treating OA, the use of natural compounds has aroused much interest among researchers due to their safety margin. Recent discovery shows that natural compounds play an extensive role in the oxidative stress signaling pathway in treating OA. Thus, this review summarizes the commonly used natural compounds for treating OA focusing on the oxidative stress signaling pathway and its downstream mediators. Selected databases—such as Scopus, Web of Science, Nature, and PubMed—were used to search for potentially relevant articles. The search is limited to the last 15 years and the search was completed using the Boolean operator’s guideline using the keywords of natural product AND oxidative stress AND osteoarthritis OR natural extract AND ROS AND degenerative arthritis OR natural plant AND free radicals AND degenerative joint disease. In total, 37 articles were selected for further review. Different downstream mechanisms of oxidative stress involved in the usage of natural compounds for OA treatment and anabolic and catabolic effects of natural compounds that exhibit chondroprotective effects have been discussed with the evidence of in vitro and in vivo trials in this review. |
| first_indexed | 2024-03-10T00:53:10Z |
| format | Article |
| id | doaj.art-ac8f95278b6d415ab80c0438af8dc9aa |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T00:53:10Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ac8f95278b6d415ab80c0438af8dc9aa2023-11-23T14:47:52ZengMDPI AGAntioxidants2076-39212022-08-01119172210.3390/antiox11091722Natural Compounds Affecting Inflammatory Pathways of OsteoarthritisYi Ting Lee0Mohd Heikal Mohd Yunus1Azizah Ugusman2Muhammad Dain Yazid3Department of Physiology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, MalaysiaCentre for Tissue Engineering Regenerative Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, MalaysiaOsteoarthritis (OA) is the most common type of arthritis and chronic joint disease, affecting more than 240 million people worldwide. Although there are numerous advances in using drugs in treating OA, the use of natural compounds has aroused much interest among researchers due to their safety margin. Recent discovery shows that natural compounds play an extensive role in the oxidative stress signaling pathway in treating OA. Thus, this review summarizes the commonly used natural compounds for treating OA focusing on the oxidative stress signaling pathway and its downstream mediators. Selected databases—such as Scopus, Web of Science, Nature, and PubMed—were used to search for potentially relevant articles. The search is limited to the last 15 years and the search was completed using the Boolean operator’s guideline using the keywords of natural product AND oxidative stress AND osteoarthritis OR natural extract AND ROS AND degenerative arthritis OR natural plant AND free radicals AND degenerative joint disease. In total, 37 articles were selected for further review. Different downstream mechanisms of oxidative stress involved in the usage of natural compounds for OA treatment and anabolic and catabolic effects of natural compounds that exhibit chondroprotective effects have been discussed with the evidence of in vitro and in vivo trials in this review.https://www.mdpi.com/2076-3921/11/9/1722natural compoundsosteoarthritisROSoxidative stressantioxidantsanabolic/catabolic effects |
| spellingShingle | Yi Ting Lee Mohd Heikal Mohd Yunus Azizah Ugusman Muhammad Dain Yazid Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis Antioxidants natural compounds osteoarthritis ROS oxidative stress antioxidants anabolic/catabolic effects |
| title | Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis |
| title_full | Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis |
| title_fullStr | Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis |
| title_full_unstemmed | Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis |
| title_short | Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis |
| title_sort | natural compounds affecting inflammatory pathways of osteoarthritis |
| topic | natural compounds osteoarthritis ROS oxidative stress antioxidants anabolic/catabolic effects |
| url | https://www.mdpi.com/2076-3921/11/9/1722 |
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