Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study
Introduction: Appropriate management of abnormal admission blood glucose level (ABGL) in acute coronary syndrome (ACS) patients still remains a common issue. This study aims to assess the influence of ABGL on development of 30-day major adverse cardiac events (MACEs) in patients with suspected ACS....
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2019-04-01
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| Series: | Archives of Academic Emergency Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/316 |
| _version_ | 1818835242937483264 |
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| author | Mostafa Alavi-Moghaddam Mohammad Parsa-Mahjoub Robabeh Ghodssi-ghassemabadi Bita Bitazar |
| author_facet | Mostafa Alavi-Moghaddam Mohammad Parsa-Mahjoub Robabeh Ghodssi-ghassemabadi Bita Bitazar |
| author_sort | Mostafa Alavi-Moghaddam |
| collection | DOAJ |
| description | Introduction: Appropriate management of abnormal admission blood glucose level (ABGL) in acute coronary syndrome (ACS) patients still remains a common issue. This study aims to assess the influence of ABGL on development of 30-day major adverse cardiac events (MACEs) in patients with suspected ACS.
Methods: This is a prospective cohort study based on analysis of data collected from patients suspected to acute coronary syndrome admitted to emergency department. ABGL of patients was measured and its association with development of MACEs (MI, CVA, mortality) within 30 days of follow-up was studied.
Results: 814 participants with the mean age of 61.8 ±13.4 years were studied (58.1% male). MACE endpoints were developed in 166 (39.0%) hyperglycemic, 30 (46.9%) hypoglycemic, and 53 (16.4%) normoglycemic patients (p<0.0001). Mean admission blood glucose level of patients who developed MACE within 30 days was significantly higher than others (210.6±123.4 vs 157.4±86.6mg/dL; p<0.0001; OR: 1.006 (1.005 to 1.008)). There was a significant correlation between male gender (p=0.027), abnormal admission blood glucose level (p<0.001), diabetes (p = 0.001), hypertension (p=0.059), prior CABG (p=0.008), first and second blood troponin levels (p<0.001), first and second abnormal ECGs (p<0.001), and also ECG changes (p<0.001) with developing AMCE. Abnormal ABGL, first and second blood troponin levels, and the history of diabetes were among independent risk factors of developing MACE within 30 days.
Conclusion: It seems that abnormal admission blood glucose level in suspected ACS patients was an independent predictor of major adverse cardiac events within 30 days. |
| first_indexed | 2024-12-19T02:47:36Z |
| format | Article |
| id | doaj.art-ac90122b56e34c638845e39088d60f87 |
| institution | Directory Open Access Journal |
| issn | 2645-4904 |
| language | English |
| last_indexed | 2024-12-19T02:47:36Z |
| publishDate | 2019-04-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj.art-ac90122b56e34c638845e39088d60f872022-12-21T20:38:48ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042019-04-017110.22037/aaem.v7i1.316316Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort StudyMostafa Alavi-MoghaddamMohammad Parsa-MahjoubRobabeh Ghodssi-ghassemabadiBita BitazarIntroduction: Appropriate management of abnormal admission blood glucose level (ABGL) in acute coronary syndrome (ACS) patients still remains a common issue. This study aims to assess the influence of ABGL on development of 30-day major adverse cardiac events (MACEs) in patients with suspected ACS. Methods: This is a prospective cohort study based on analysis of data collected from patients suspected to acute coronary syndrome admitted to emergency department. ABGL of patients was measured and its association with development of MACEs (MI, CVA, mortality) within 30 days of follow-up was studied. Results: 814 participants with the mean age of 61.8 ±13.4 years were studied (58.1% male). MACE endpoints were developed in 166 (39.0%) hyperglycemic, 30 (46.9%) hypoglycemic, and 53 (16.4%) normoglycemic patients (p<0.0001). Mean admission blood glucose level of patients who developed MACE within 30 days was significantly higher than others (210.6±123.4 vs 157.4±86.6mg/dL; p<0.0001; OR: 1.006 (1.005 to 1.008)). There was a significant correlation between male gender (p=0.027), abnormal admission blood glucose level (p<0.001), diabetes (p = 0.001), hypertension (p=0.059), prior CABG (p=0.008), first and second blood troponin levels (p<0.001), first and second abnormal ECGs (p<0.001), and also ECG changes (p<0.001) with developing AMCE. Abnormal ABGL, first and second blood troponin levels, and the history of diabetes were among independent risk factors of developing MACE within 30 days. Conclusion: It seems that abnormal admission blood glucose level in suspected ACS patients was an independent predictor of major adverse cardiac events within 30 days.https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/316Blood glucoseacute coronary syndromemyocardial infarctionstrokedeath |
| spellingShingle | Mostafa Alavi-Moghaddam Mohammad Parsa-Mahjoub Robabeh Ghodssi-ghassemabadi Bita Bitazar Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study Archives of Academic Emergency Medicine Blood glucose acute coronary syndrome myocardial infarction stroke death |
| title | Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study |
| title_full | Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study |
| title_fullStr | Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study |
| title_full_unstemmed | Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study |
| title_short | Association of Admission Blood Glucose Level with Major Adverse Cardiac Events in Acute Coronary Syndrome; a Cohort Study |
| title_sort | association of admission blood glucose level with major adverse cardiac events in acute coronary syndrome a cohort study |
| topic | Blood glucose acute coronary syndrome myocardial infarction stroke death |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/316 |
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