High expression of TIG3 predicts poor survival in patients with primary glioblastoma
TIG3 (tazarotene-induced gene 3) has been reported to suppress the progression of several malignancies, where this gene is universally downregulated. However, the expression of TIG3 in primary glioblastoma and its relevance to patient’s prognosis have not been elaborated. Thus, this study was aimed...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOS Press
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317712135 |
| _version_ | 1818865902301478912 |
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| author | Hongxiang Wang Hanchong Xu Tao Xu Cong Tan Mei Jiang Yihong Chen Xinyu Hu Jinxu Zhou Junyan Shen Rong Qin Daiyu Hu Qilin Huang Min Wang Lian Wang Dongxia Duan Yong Yan Juxiang Chen |
| author_facet | Hongxiang Wang Hanchong Xu Tao Xu Cong Tan Mei Jiang Yihong Chen Xinyu Hu Jinxu Zhou Junyan Shen Rong Qin Daiyu Hu Qilin Huang Min Wang Lian Wang Dongxia Duan Yong Yan Juxiang Chen |
| author_sort | Hongxiang Wang |
| collection | DOAJ |
| description | TIG3 (tazarotene-induced gene 3) has been reported to suppress the progression of several malignancies, where this gene is universally downregulated. However, the expression of TIG3 in primary glioblastoma and its relevance to patient’s prognosis have not been elaborated. Thus, this study was aimed to evaluate TIG3 expression level in primary glioblastoma and investigate the prognostic value of TIG3 for patients. The Cancer Genome Atlas database was first utilized to analyze the expression and prognostic potential of TIG3 in 528 glioblastoma cases. Compared with control group, glioblastoma showed significantly elevated TIG3 expression (p < 0.001). Log-rank analysis revealed that higher expression of TIG3 was associated with shorter overall survival (358vs 383 days, p = 0.039). Furthermore, TIG3 protein expression detected by immunohistochemistry confirmed positive correlation of TIG3 expression and glioma grade and upregulation of TIG3 in our cohort of 101 primary glioblastoma patients compared to 16 normal brains. Finally, Kaplan–Meier analysis and Cox regression analysis identified high TIG3 expression as an independent risk factor for overall survival of primary glioblastoma patients (overall survival, 10 vs 13 months, p = 0.033; hazard ratio = 1.542, p = 0.046). Together, this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma. |
| first_indexed | 2024-12-19T10:54:55Z |
| format | Article |
| id | doaj.art-ac910ef4ff004c9493cb2675cce4aeb6 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-19T10:54:55Z |
| publishDate | 2017-06-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-ac910ef4ff004c9493cb2675cce4aeb62022-12-21T20:24:51ZengIOS PressTumor Biology1423-03802017-06-013910.1177/1010428317712135High expression of TIG3 predicts poor survival in patients with primary glioblastomaHongxiang Wang0Hanchong Xu1Tao Xu2Cong Tan3Mei Jiang4Yihong Chen5Xinyu Hu6Jinxu Zhou7Junyan Shen8Rong Qin9Daiyu Hu10Qilin Huang11Min Wang12Lian Wang13Dongxia Duan14Yong Yan15Juxiang Chen16Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, The 101th Hospital of PLA, Wuxi, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, The 184th Hospital of PLA, Yingtan, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Regenerative Medicine, Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaTIG3 (tazarotene-induced gene 3) has been reported to suppress the progression of several malignancies, where this gene is universally downregulated. However, the expression of TIG3 in primary glioblastoma and its relevance to patient’s prognosis have not been elaborated. Thus, this study was aimed to evaluate TIG3 expression level in primary glioblastoma and investigate the prognostic value of TIG3 for patients. The Cancer Genome Atlas database was first utilized to analyze the expression and prognostic potential of TIG3 in 528 glioblastoma cases. Compared with control group, glioblastoma showed significantly elevated TIG3 expression (p < 0.001). Log-rank analysis revealed that higher expression of TIG3 was associated with shorter overall survival (358vs 383 days, p = 0.039). Furthermore, TIG3 protein expression detected by immunohistochemistry confirmed positive correlation of TIG3 expression and glioma grade and upregulation of TIG3 in our cohort of 101 primary glioblastoma patients compared to 16 normal brains. Finally, Kaplan–Meier analysis and Cox regression analysis identified high TIG3 expression as an independent risk factor for overall survival of primary glioblastoma patients (overall survival, 10 vs 13 months, p = 0.033; hazard ratio = 1.542, p = 0.046). Together, this study indicated that increased expression of TIG3 in primary glioblastoma is a novel biomarker for predicting poor outcome of patients. We then hypothesize that TIG3 may function in a different pattern in glioblastoma.https://doi.org/10.1177/1010428317712135 |
| spellingShingle | Hongxiang Wang Hanchong Xu Tao Xu Cong Tan Mei Jiang Yihong Chen Xinyu Hu Jinxu Zhou Junyan Shen Rong Qin Daiyu Hu Qilin Huang Min Wang Lian Wang Dongxia Duan Yong Yan Juxiang Chen High expression of TIG3 predicts poor survival in patients with primary glioblastoma Tumor Biology |
| title | High expression of TIG3 predicts poor survival in patients with primary glioblastoma |
| title_full | High expression of TIG3 predicts poor survival in patients with primary glioblastoma |
| title_fullStr | High expression of TIG3 predicts poor survival in patients with primary glioblastoma |
| title_full_unstemmed | High expression of TIG3 predicts poor survival in patients with primary glioblastoma |
| title_short | High expression of TIG3 predicts poor survival in patients with primary glioblastoma |
| title_sort | high expression of tig3 predicts poor survival in patients with primary glioblastoma |
| url | https://doi.org/10.1177/1010428317712135 |
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