Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study
Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/20/5037 |
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| author | Ana Morelló-Vicente Marta Espejo-Marín Inés Oteiza-Rius Javier Antoñanzas Antonio Vélez Rafael Salido-Vallejo |
| author_facet | Ana Morelló-Vicente Marta Espejo-Marín Inés Oteiza-Rius Javier Antoñanzas Antonio Vélez Rafael Salido-Vallejo |
| author_sort | Ana Morelló-Vicente |
| collection | DOAJ |
| description | Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is to compare the risk of local recurrence and metastases in patients with cSCC in highly sun-exposed areas compared to cSCC in less sun-exposed areas. Material and methods: A retrospective observational study was carried out, including 558 patients with histopathologically confirmed cSCC at the Reina Sofía University Hospital (HURS), Córdoba, during the period from 1 January 2017 to 31 December 2020. Demographic, clinical and anatomopathological data were collected. Results: Local recurrence occurs more often in highly sun-exposed areas (15.8%) compared to less sun-exposed ones (7.4%) (<i>p</i> < 0.05). However, no differences in the rate of metastases in both groups were found. The presence of affected surgical margins and tumor thickness were identified as independent risk factors for cSCC in low sun-exposure areas. Conclusions: cSCC located in anatomical areas of high sun exposure presented a greater risk of developing local recurrence in our population, which could suggest that these tumors have worse prognosis than those that lie in areas that do not receive chronic sun exposure. |
| first_indexed | 2024-03-10T21:21:49Z |
| format | Article |
| id | doaj.art-ac935c29542d4a6190491247d59cbb5e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:21:49Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ac935c29542d4a6190491247d59cbb5e2023-11-19T15:59:40ZengMDPI AGCancers2072-66942023-10-011520503710.3390/cancers15205037Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort StudyAna Morelló-Vicente0Marta Espejo-Marín1Inés Oteiza-Rius2Javier Antoñanzas3Antonio Vélez4Rafael Salido-Vallejo5Dermatology Department, University Clinic of Navarra, 31008 Pamplona, SpainOccidente-Azahara Health Care Center, 14005 Córdoba, SpainDermatology Department, University Clinic of Navarra, 31008 Pamplona, SpainDermatology Department, University Clinic of Navarra, 31008 Pamplona, SpainDermatology Department, Reina Sofía University Hospital, 14004 Córdoba, SpainDermatology Department, University Clinic of Navarra, 31008 Pamplona, SpainBackground: The incidence of cutaneous squamous cell carcinoma (cSCC) is increasing over the years. Risk factors for local recurrence and metastasis have been widely studied in highly sun-exposed areas of the body but less data exist about less sun-exposed ones. The main objective of this study is to compare the risk of local recurrence and metastases in patients with cSCC in highly sun-exposed areas compared to cSCC in less sun-exposed areas. Material and methods: A retrospective observational study was carried out, including 558 patients with histopathologically confirmed cSCC at the Reina Sofía University Hospital (HURS), Córdoba, during the period from 1 January 2017 to 31 December 2020. Demographic, clinical and anatomopathological data were collected. Results: Local recurrence occurs more often in highly sun-exposed areas (15.8%) compared to less sun-exposed ones (7.4%) (<i>p</i> < 0.05). However, no differences in the rate of metastases in both groups were found. The presence of affected surgical margins and tumor thickness were identified as independent risk factors for cSCC in low sun-exposure areas. Conclusions: cSCC located in anatomical areas of high sun exposure presented a greater risk of developing local recurrence in our population, which could suggest that these tumors have worse prognosis than those that lie in areas that do not receive chronic sun exposure.https://www.mdpi.com/2072-6694/15/20/5037cutaneous squamous cell carcinomalocal recurrencemetastasessun exposure |
| spellingShingle | Ana Morelló-Vicente Marta Espejo-Marín Inés Oteiza-Rius Javier Antoñanzas Antonio Vélez Rafael Salido-Vallejo Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study Cancers cutaneous squamous cell carcinoma local recurrence metastases sun exposure |
| title | Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study |
| title_full | Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study |
| title_fullStr | Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study |
| title_full_unstemmed | Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study |
| title_short | Increased Risk of Local Recurrence in Cutaneous Squamous Cell Carcinoma Arising in Sun-Exposed Skin: A Retrospective Cohort Study |
| title_sort | increased risk of local recurrence in cutaneous squamous cell carcinoma arising in sun exposed skin a retrospective cohort study |
| topic | cutaneous squamous cell carcinoma local recurrence metastases sun exposure |
| url | https://www.mdpi.com/2072-6694/15/20/5037 |
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