Advancements in the Alcohol-Associated Liver Disease Model
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad spectrum of liver damage. The presentation of ALD can include simple steatosis, steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). Effective prevention and treatment strategies ar...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/8/1035 |
| _version_ | 1797432447903727616 |
|---|---|
| author | Lin Zhu Hai-Di Li Jie-Jie Xu Juan-Juan Li Miao Cheng Xiao-Ming Meng Cheng Huang Jun Li |
| author_facet | Lin Zhu Hai-Di Li Jie-Jie Xu Juan-Juan Li Miao Cheng Xiao-Ming Meng Cheng Huang Jun Li |
| author_sort | Lin Zhu |
| collection | DOAJ |
| description | Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad spectrum of liver damage. The presentation of ALD can include simple steatosis, steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). Effective prevention and treatment strategies are urgently required for ALD patients. In previous decades, numerous rodent models were established to investigate the mechanisms of alcohol-associated liver disease and explore therapeutic targets. This review provides a summary of the latest developments in rodent models, including those that involve EtOH administration, which will help us to understand the characteristics and causes of ALD at different stages. In addition, we discuss the pathogenesis of ALD and summarize the existing in vitro models. We analyse the pros and cons of these models and their translational relevance and summarize the insights that have been gained regarding the mechanisms of alcoholic liver injury. |
| first_indexed | 2024-03-09T10:00:39Z |
| format | Article |
| id | doaj.art-ac9392c5e1e94cf0aa9a96a3b8e41581 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:00:39Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ac9392c5e1e94cf0aa9a96a3b8e415812023-12-01T23:28:44ZengMDPI AGBiomolecules2218-273X2022-07-01128103510.3390/biom12081035Advancements in the Alcohol-Associated Liver Disease ModelLin Zhu0Hai-Di Li1Jie-Jie Xu2Juan-Juan Li3Miao Cheng4Xiao-Ming Meng5Cheng Huang6Jun Li7Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaAlcohol-associated liver disease (ALD) is an intricate disease that results in a broad spectrum of liver damage. The presentation of ALD can include simple steatosis, steatohepatitis, liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). Effective prevention and treatment strategies are urgently required for ALD patients. In previous decades, numerous rodent models were established to investigate the mechanisms of alcohol-associated liver disease and explore therapeutic targets. This review provides a summary of the latest developments in rodent models, including those that involve EtOH administration, which will help us to understand the characteristics and causes of ALD at different stages. In addition, we discuss the pathogenesis of ALD and summarize the existing in vitro models. We analyse the pros and cons of these models and their translational relevance and summarize the insights that have been gained regarding the mechanisms of alcoholic liver injury.https://www.mdpi.com/2218-273X/12/8/1035alcoholalcohol-associated liver diseasepathological processesin vitro modelin vivo model |
| spellingShingle | Lin Zhu Hai-Di Li Jie-Jie Xu Juan-Juan Li Miao Cheng Xiao-Ming Meng Cheng Huang Jun Li Advancements in the Alcohol-Associated Liver Disease Model Biomolecules alcohol alcohol-associated liver disease pathological processes in vitro model in vivo model |
| title | Advancements in the Alcohol-Associated Liver Disease Model |
| title_full | Advancements in the Alcohol-Associated Liver Disease Model |
| title_fullStr | Advancements in the Alcohol-Associated Liver Disease Model |
| title_full_unstemmed | Advancements in the Alcohol-Associated Liver Disease Model |
| title_short | Advancements in the Alcohol-Associated Liver Disease Model |
| title_sort | advancements in the alcohol associated liver disease model |
| topic | alcohol alcohol-associated liver disease pathological processes in vitro model in vivo model |
| url | https://www.mdpi.com/2218-273X/12/8/1035 |
| work_keys_str_mv | AT linzhu advancementsinthealcoholassociatedliverdiseasemodel AT haidili advancementsinthealcoholassociatedliverdiseasemodel AT jiejiexu advancementsinthealcoholassociatedliverdiseasemodel AT juanjuanli advancementsinthealcoholassociatedliverdiseasemodel AT miaocheng advancementsinthealcoholassociatedliverdiseasemodel AT xiaomingmeng advancementsinthealcoholassociatedliverdiseasemodel AT chenghuang advancementsinthealcoholassociatedliverdiseasemodel AT junli advancementsinthealcoholassociatedliverdiseasemodel |