Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists
The chikungunya virus (CHIKV) is spread by <i>Aedes aegypti</i> and <i>Ae. albopictus</i> mosquitos worldwide; infection can lead to disease including joint pain, fever, and rash, with some convalescent persons experiencing chronic symptoms. Historically, CHIKV transmission h...
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MDPI AG
2019-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/8/3/113 |
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| author | Mame Cheikh Seck Aida Sadikh Badiane Julie Thwing Delynn Moss Fatou Ba Fall Jules Francois Gomis Awa Bineta Deme Khadim Diongue Mohamed Sy Aminata Mbaye Tolla Ndiaye Aminata Gaye Yaye Die Ndiaye Mamadou Alpha Diallo Daouda Ndiaye Eric Rogier |
| author_facet | Mame Cheikh Seck Aida Sadikh Badiane Julie Thwing Delynn Moss Fatou Ba Fall Jules Francois Gomis Awa Bineta Deme Khadim Diongue Mohamed Sy Aminata Mbaye Tolla Ndiaye Aminata Gaye Yaye Die Ndiaye Mamadou Alpha Diallo Daouda Ndiaye Eric Rogier |
| author_sort | Mame Cheikh Seck |
| collection | DOAJ |
| description | The chikungunya virus (CHIKV) is spread by <i>Aedes aegypti</i> and <i>Ae. albopictus</i> mosquitos worldwide; infection can lead to disease including joint pain, fever, and rash, with some convalescent persons experiencing chronic symptoms. Historically, CHIKV transmission has occurred in Africa and Asia, but recent outbreaks have taken place in Europe, Indonesia, and the Americas. From September to October 2014, a survey was undertaken with nomadic pastoralists residing in the northeast departments of Senegal. Blood dried on filter paper (dried blood spots; DBS) were collected from 1465 participants of all ages, and assayed for Immunoglobulin G (IgG) antibodies against CHIKV E1 antigen by a bead-based multiplex assay. The overall seroprevalence of all participants to CHIKV E1 was 2.7%, with no persons under 10 years of age found to be antibody positive. Above 10 years of age, clear increases of seroprevalence and IgG levels were observed with increasing age; 7.6% of participants older than 50 years were found to be positive for anti-CHIKV IgG. Reported net ownership, net usage, and gender were all non-significant explanatory variables of seropositivity. These data show a low-level historical exposure of this pastoralist population to CHIKV, with no evidence of recent CHIKV transmission in the past decade. |
| first_indexed | 2024-04-11T12:32:32Z |
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| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T12:32:32Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-ac95305f73a244aba61bb255d0b8ed8f2022-12-22T04:23:43ZengMDPI AGPathogens2076-08172019-07-018311310.3390/pathogens8030113pathogens8030113Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic PastoralistsMame Cheikh Seck0Aida Sadikh Badiane1Julie Thwing2Delynn Moss3Fatou Ba Fall4Jules Francois Gomis5Awa Bineta Deme6Khadim Diongue7Mohamed Sy8Aminata Mbaye9Tolla Ndiaye10Aminata Gaye11Yaye Die Ndiaye12Mamadou Alpha Diallo13Daouda Ndiaye14Eric Rogier15Department of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, USADivision of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USASenegal National Malaria Control Program, Dakar 999066, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalDepartment of Parasitology, Faculty of Medicine and Pharmacy, Cheikh Anta Diop University, Dakar 12500, SenegalMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA 30333, USAThe chikungunya virus (CHIKV) is spread by <i>Aedes aegypti</i> and <i>Ae. albopictus</i> mosquitos worldwide; infection can lead to disease including joint pain, fever, and rash, with some convalescent persons experiencing chronic symptoms. Historically, CHIKV transmission has occurred in Africa and Asia, but recent outbreaks have taken place in Europe, Indonesia, and the Americas. From September to October 2014, a survey was undertaken with nomadic pastoralists residing in the northeast departments of Senegal. Blood dried on filter paper (dried blood spots; DBS) were collected from 1465 participants of all ages, and assayed for Immunoglobulin G (IgG) antibodies against CHIKV E1 antigen by a bead-based multiplex assay. The overall seroprevalence of all participants to CHIKV E1 was 2.7%, with no persons under 10 years of age found to be antibody positive. Above 10 years of age, clear increases of seroprevalence and IgG levels were observed with increasing age; 7.6% of participants older than 50 years were found to be positive for anti-CHIKV IgG. Reported net ownership, net usage, and gender were all non-significant explanatory variables of seropositivity. These data show a low-level historical exposure of this pastoralist population to CHIKV, with no evidence of recent CHIKV transmission in the past decade.https://www.mdpi.com/2076-0817/8/3/113serologychikungunyaseroprevalencenomadic pastoralistsSenegalmultiplex bead assay |
| spellingShingle | Mame Cheikh Seck Aida Sadikh Badiane Julie Thwing Delynn Moss Fatou Ba Fall Jules Francois Gomis Awa Bineta Deme Khadim Diongue Mohamed Sy Aminata Mbaye Tolla Ndiaye Aminata Gaye Yaye Die Ndiaye Mamadou Alpha Diallo Daouda Ndiaye Eric Rogier Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists Pathogens serology chikungunya seroprevalence nomadic pastoralists Senegal multiplex bead assay |
| title | Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists |
| title_full | Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists |
| title_fullStr | Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists |
| title_full_unstemmed | Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists |
| title_short | Serological Data Shows Low Levels of Chikungunya Exposure in Senegalese Nomadic Pastoralists |
| title_sort | serological data shows low levels of chikungunya exposure in senegalese nomadic pastoralists |
| topic | serology chikungunya seroprevalence nomadic pastoralists Senegal multiplex bead assay |
| url | https://www.mdpi.com/2076-0817/8/3/113 |
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