Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers
Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative treatment options are available, such as joint...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/2/180 |
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| author | Kaoru Aoki Hirokazu Ideta Yukiko Komatsu Atsushi Tanaka Munehisa Kito Masanori Okamoto Jun Takahashi Shuichiro Suzuki Naoto Saito |
| author_facet | Kaoru Aoki Hirokazu Ideta Yukiko Komatsu Atsushi Tanaka Munehisa Kito Masanori Okamoto Jun Takahashi Shuichiro Suzuki Naoto Saito |
| author_sort | Kaoru Aoki |
| collection | DOAJ |
| description | Calcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative treatment options are available, such as joint arthroplasty, autologous bone grafting, and allogeneic bone grafting. Although various biodegradable polymers are also being developed as synthetic bone material in scaffolds for regenerative medicine, the clinical application of commercial synthetic bone products with comparable performance to that of calcium phosphate bioceramics have yet to be realized. This review discusses the status quo of bone-regeneration therapy using artificial bone composed of calcium phosphate bioceramics such as β-tricalcium phosphate (βTCP), carbonate apatite, and hydroxyapatite (HA), in addition to the recent use of calcium phosphate bioceramics, biodegradable polymers, and their composites. New research has introduced potential materials such as octacalcium phosphate (OCP), biologically derived polymers, and synthetic biodegradable polymers. The performance of artificial bone is intricately related to conditions such as the intrinsic material, degradability, composite materials, manufacturing method, structure, and signaling molecules such as growth factors and cells. The development of new scaffold materials may offer more efficient bone regeneration. |
| first_indexed | 2024-03-07T22:41:55Z |
| format | Article |
| id | doaj.art-ac9555e08f3a40a39348d064136067e6 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-07T22:41:55Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-ac9555e08f3a40a39348d064136067e62024-02-23T15:08:01ZengMDPI AGBioengineering2306-53542024-02-0111218010.3390/bioengineering11020180Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable PolymersKaoru Aoki0Hirokazu Ideta1Yukiko Komatsu2Atsushi Tanaka3Munehisa Kito4Masanori Okamoto5Jun Takahashi6Shuichiro Suzuki7Naoto Saito8Physical Therapy Division, School of Health Sciences, Shinshu University, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto 390-8621, JapanDepartment of Orthopaedic Surgery, Matsumoto Medical Center, Matsumoto 390-8621, JapanInstitute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, Matsumoto 390-8621, JapanCalcium phosphate-based synthetic bone is broadly used for the clinical treatment of bone defects caused by trauma and bone tumors. Synthetic bone is easy to use; however, its effects depend on the size and location of the bone defect. Many alternative treatment options are available, such as joint arthroplasty, autologous bone grafting, and allogeneic bone grafting. Although various biodegradable polymers are also being developed as synthetic bone material in scaffolds for regenerative medicine, the clinical application of commercial synthetic bone products with comparable performance to that of calcium phosphate bioceramics have yet to be realized. This review discusses the status quo of bone-regeneration therapy using artificial bone composed of calcium phosphate bioceramics such as β-tricalcium phosphate (βTCP), carbonate apatite, and hydroxyapatite (HA), in addition to the recent use of calcium phosphate bioceramics, biodegradable polymers, and their composites. New research has introduced potential materials such as octacalcium phosphate (OCP), biologically derived polymers, and synthetic biodegradable polymers. The performance of artificial bone is intricately related to conditions such as the intrinsic material, degradability, composite materials, manufacturing method, structure, and signaling molecules such as growth factors and cells. The development of new scaffold materials may offer more efficient bone regeneration.https://www.mdpi.com/2306-5354/11/2/180bone defectbone regenerationscaffoldcalcium phosphatebiodegradable polymer |
| spellingShingle | Kaoru Aoki Hirokazu Ideta Yukiko Komatsu Atsushi Tanaka Munehisa Kito Masanori Okamoto Jun Takahashi Shuichiro Suzuki Naoto Saito Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers Bioengineering bone defect bone regeneration scaffold calcium phosphate biodegradable polymer |
| title | Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers |
| title_full | Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers |
| title_fullStr | Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers |
| title_full_unstemmed | Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers |
| title_short | Bone-Regeneration Therapy Using Biodegradable Scaffolds: Calcium Phosphate Bioceramics and Biodegradable Polymers |
| title_sort | bone regeneration therapy using biodegradable scaffolds calcium phosphate bioceramics and biodegradable polymers |
| topic | bone defect bone regeneration scaffold calcium phosphate biodegradable polymer |
| url | https://www.mdpi.com/2306-5354/11/2/180 |
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