Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
ABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a resu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2017-05-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.00354-17 |
| _version_ | 1818739498274521088 |
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| author | Jun-Seob Kim Thomas K. Wood |
| author_facet | Jun-Seob Kim Thomas K. Wood |
| author_sort | Jun-Seob Kim |
| collection | DOAJ |
| description | ABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population. |
| first_indexed | 2024-12-18T01:25:47Z |
| format | Article |
| id | doaj.art-ac9658f524614a788ce887251bff024c |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-12-18T01:25:47Z |
| publishDate | 2017-05-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-ac9658f524614a788ce887251bff024c2022-12-21T21:25:44ZengAmerican Society for MicrobiologymBio2150-75112017-05-018210.1128/mBio.00354-17Tolerant, Growing Cells from Nutrient Shifts Are Not Persister CellsJun-Seob Kim0Thomas K. Wood1Department of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, USADepartment of Chemical Engineering, Pennsylvania State University, University Park, Pennsylvania, USAABSTRACT There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and growing cell populations (e.g., as a result of nutrient shifts) and attributing the phenotypes that they discern to persister cells while other labs are studying dormant cells. We argue here that the metabolically active cell population should more accurately be considered tolerant cells, while the dormant cells are the true persister population.https://journals.asm.org/doi/10.1128/mBio.00354-17antimicrobial agentspersistencetolerance |
| spellingShingle | Jun-Seob Kim Thomas K. Wood Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells mBio antimicrobial agents persistence tolerance |
| title | Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells |
| title_full | Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells |
| title_fullStr | Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells |
| title_full_unstemmed | Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells |
| title_short | Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells |
| title_sort | tolerant growing cells from nutrient shifts are not persister cells |
| topic | antimicrobial agents persistence tolerance |
| url | https://journals.asm.org/doi/10.1128/mBio.00354-17 |
| work_keys_str_mv | AT junseobkim tolerantgrowingcellsfromnutrientshiftsarenotpersistercells AT thomaskwood tolerantgrowingcellsfromnutrientshiftsarenotpersistercells |