Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function
<b>Purpose:</b> In recent years, cardiac magnetic resonance (CMR) has been used to assess LV diastolic function. In this systematic review, studies were identified where CMR parameters had been evaluated in healthy and/or patient groups with proven diastolic dysfunction or known to devel...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/7/1282 |
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| author | Annemie Stege Bojer Martin Heyn Soerensen Peter Gaede Saul Myerson Per Lav Madsen |
| author_facet | Annemie Stege Bojer Martin Heyn Soerensen Peter Gaede Saul Myerson Per Lav Madsen |
| author_sort | Annemie Stege Bojer |
| collection | DOAJ |
| description | <b>Purpose:</b> In recent years, cardiac magnetic resonance (CMR) has been used to assess LV diastolic function. In this systematic review, studies were identified where CMR parameters had been evaluated in healthy and/or patient groups with proven diastolic dysfunction or known to develop heart failure with preserved ejection fraction. We aimed at describing the parameters most often used, thresholds where possible, and correlation to echocardiographic and invasive measurements. <b>Methods and results:</b> A systematic literature review was performed using the databases of PubMed, Embase, and Cochrane. In total, 3808 articles were screened, and 102 studies were included. Four main CMR techniques were identified: tagging; time/volume curves; mitral inflow quantification with velocity-encoded phase-contrast sequences; and feature tracking. Techniques were described and estimates were presented in tables. From published studies, peak change of torsion shear angle versus volume changes in early diastole (−dφ′/dV′) (from tagging analysis), early peak filling rate indexed to LV end-diastolic volume <2.1 s<sup>−1</sup> (from LV time-volume curve analysis), enlarged LA maximal volume >52 mL/m<sup>2</sup>, lowered LA total (<40%), and lowered LA passive emptying fractions (<16%) seem to be reliable measures of LV diastolic dysfunction. Feature tracking, especially of the atrium, shows promise but is still a novel technique. <b>Conclusion:</b> CMR techniques of LV untwisting and early filling and LA measures of poor emptying are promising for the diagnosis of LV filling impairment, but further research in long-term follow-up studies is needed to assess the ability for the parameters to predict patient related outcomes. |
| first_indexed | 2024-03-10T09:42:20Z |
| format | Article |
| id | doaj.art-ac96d1a221cb4cf9973b6bc84f7ba493 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T09:42:20Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-ac96d1a221cb4cf9973b6bc84f7ba4932023-11-22T03:35:31ZengMDPI AGDiagnostics2075-44182021-07-01117128210.3390/diagnostics11071282Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic FunctionAnnemie Stege Bojer0Martin Heyn Soerensen1Peter Gaede2Saul Myerson3Per Lav Madsen4Department of Cardiology and Endocrinology, Slagelse Hospital, 4200 Slagelse, DenmarkDepartment of Cardiology and Endocrinology, Slagelse Hospital, 4200 Slagelse, DenmarkDepartment of Cardiology and Endocrinology, Slagelse Hospital, 4200 Slagelse, DenmarkCentre for Clinical Magnetic Resonance Research, University of Oxford, Oxford OX1 2JD, UKDepartment of Cardiology, Copenhagen University Hospital, 2730 Herlev, Denmark<b>Purpose:</b> In recent years, cardiac magnetic resonance (CMR) has been used to assess LV diastolic function. In this systematic review, studies were identified where CMR parameters had been evaluated in healthy and/or patient groups with proven diastolic dysfunction or known to develop heart failure with preserved ejection fraction. We aimed at describing the parameters most often used, thresholds where possible, and correlation to echocardiographic and invasive measurements. <b>Methods and results:</b> A systematic literature review was performed using the databases of PubMed, Embase, and Cochrane. In total, 3808 articles were screened, and 102 studies were included. Four main CMR techniques were identified: tagging; time/volume curves; mitral inflow quantification with velocity-encoded phase-contrast sequences; and feature tracking. Techniques were described and estimates were presented in tables. From published studies, peak change of torsion shear angle versus volume changes in early diastole (−dφ′/dV′) (from tagging analysis), early peak filling rate indexed to LV end-diastolic volume <2.1 s<sup>−1</sup> (from LV time-volume curve analysis), enlarged LA maximal volume >52 mL/m<sup>2</sup>, lowered LA total (<40%), and lowered LA passive emptying fractions (<16%) seem to be reliable measures of LV diastolic dysfunction. Feature tracking, especially of the atrium, shows promise but is still a novel technique. <b>Conclusion:</b> CMR techniques of LV untwisting and early filling and LA measures of poor emptying are promising for the diagnosis of LV filling impairment, but further research in long-term follow-up studies is needed to assess the ability for the parameters to predict patient related outcomes.https://www.mdpi.com/2075-4418/11/7/1282cardiovascular magnetic resonancediastologytaggingleft ventricle time-volume curvepeak filling ratefeature tracking |
| spellingShingle | Annemie Stege Bojer Martin Heyn Soerensen Peter Gaede Saul Myerson Per Lav Madsen Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function Diagnostics cardiovascular magnetic resonance diastology tagging left ventricle time-volume curve peak filling rate feature tracking |
| title | Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function |
| title_full | Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function |
| title_fullStr | Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function |
| title_full_unstemmed | Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function |
| title_short | Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function |
| title_sort | left ventricular diastolic function studied with magnetic resonance imaging a systematic review of techniques and relation to established measures of diastolic function |
| topic | cardiovascular magnetic resonance diastology tagging left ventricle time-volume curve peak filling rate feature tracking |
| url | https://www.mdpi.com/2075-4418/11/7/1282 |
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