Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives
Molecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease processes can be derived and treatment strategies can be...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/4/432 |
| _version_ | 1797409759780929536 |
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| author | Manja Kubeil Irma Ivette Santana Martínez Michael Bachmann Klaus Kopka Kellie L. Tuck Holger Stephan |
| author_facet | Manja Kubeil Irma Ivette Santana Martínez Michael Bachmann Klaus Kopka Kellie L. Tuck Holger Stephan |
| author_sort | Manja Kubeil |
| collection | DOAJ |
| description | Molecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease processes can be derived and treatment strategies can be planned. In this context, methods that combine several modalities in one probe are increasingly being used. Due to the comparably high sensitivity and provided complementary information, the combination of nuclear and optical probes has taken on a special significance. In this review article, dual-labelled systems for bimodal nuclear and optical imaging based on both modular ligands and nanomaterials are discussed. Particular attention is paid to radiometal-labelled molecules for single-photon emission computed tomography (SPECT) and positron emission tomography (PET) and metal complexes combined with fluorescent dyes for optical imaging. The clinical potential of such probes, especially for fluorescence-guided surgery, is assessed. |
| first_indexed | 2024-03-09T04:19:16Z |
| format | Article |
| id | doaj.art-ac96f5cb53204ce0a7c9cef44a2ff19a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T04:19:16Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ac96f5cb53204ce0a7c9cef44a2ff19a2023-12-03T13:49:35ZengMDPI AGPharmaceuticals1424-82472022-03-0115443210.3390/ph15040432Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future PerspectivesManja Kubeil0Irma Ivette Santana Martínez1Michael Bachmann2Klaus Kopka3Kellie L. Tuck4Holger Stephan5Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, GermanyHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, GermanyHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, GermanyHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, GermanySchool of Chemistry, Monash University, Melbourne, VIC 3800, AustraliaHelmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Bautzner Landstraße 400, 01328 Dresden, GermanyMolecular imaging offers the possibility to investigate biological and biochemical processes non-invasively and to obtain information on both anatomy and dysfunctions. Based on the data obtained, a fundamental understanding of various disease processes can be derived and treatment strategies can be planned. In this context, methods that combine several modalities in one probe are increasingly being used. Due to the comparably high sensitivity and provided complementary information, the combination of nuclear and optical probes has taken on a special significance. In this review article, dual-labelled systems for bimodal nuclear and optical imaging based on both modular ligands and nanomaterials are discussed. Particular attention is paid to radiometal-labelled molecules for single-photon emission computed tomography (SPECT) and positron emission tomography (PET) and metal complexes combined with fluorescent dyes for optical imaging. The clinical potential of such probes, especially for fluorescence-guided surgery, is assessed.https://www.mdpi.com/1424-8247/15/4/432molecular imagingpositron emission tomographysingle-photon emission computed tomographynear-infrared fluorescence |
| spellingShingle | Manja Kubeil Irma Ivette Santana Martínez Michael Bachmann Klaus Kopka Kellie L. Tuck Holger Stephan Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives Pharmaceuticals molecular imaging positron emission tomography single-photon emission computed tomography near-infrared fluorescence |
| title | Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives |
| title_full | Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives |
| title_fullStr | Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives |
| title_full_unstemmed | Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives |
| title_short | Dual-Labelling Strategies for Nuclear and Fluorescence Molecular Imaging: Current Status and Future Perspectives |
| title_sort | dual labelling strategies for nuclear and fluorescence molecular imaging current status and future perspectives |
| topic | molecular imaging positron emission tomography single-photon emission computed tomography near-infrared fluorescence |
| url | https://www.mdpi.com/1424-8247/15/4/432 |
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