How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature
Arif Budiman,1,* Agus Rusdin,2,* Laila Subra,3 Diah Lia Aulifa2,* 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty o...
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| Format: | Article |
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Dove Medical Press
2023-09-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/how-key-alterations-of-mesoporous-silica-nanoparticles-affect-anti-lun-peer-reviewed-fulltext-article-IJN |
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| author | Budiman A Rusdin A Subra L Aulifa DL |
| author_facet | Budiman A Rusdin A Subra L Aulifa DL |
| author_sort | Budiman A |
| collection | DOAJ |
| description | Arif Budiman,1,* Agus Rusdin,2,* Laila Subra,3 Diah Lia Aulifa2,* 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department of Pharmacy, faculty of Bioeconomic, Food and Health Sciences, Universiti Geomatika Malaysia, Kuala Lumpur, Malaysia*These authors contributed equally to this workCorrespondence: Diah Lia Aulifa, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km. 21, Sumedang, West Java, 45363, Indonesia, Email diah.lia@unpad.ac.idAbstract: In 2020, there were 2.21 million new instances of lung cancer, making it the top cause of mortality globally, responsible for close to 10 million deaths. The physicochemical problems of chemotherapy drugs are the primary challenge that now causes a drug’s low effectiveness. Solubility is a physicochemical factor that has a significant impact on a drug’s biopharmaceutical properties, starting with the rate at which it dissolves and extending through how well it is absorbed and bioavailable. One of the most well-known methods for addressing a drug’s solubility is mesoporous silica, which has undergone excellent development due to the conjugation of polymers and ligands that increase its effectiveness. However, there are still very few papers addressing the success of this discovery, particularly those addressing its molecular pharmaceutics and mechanism. Our study’s objectives were to explore and summarize the effects of targeting mediator on drug development using mesoporous silica with and without functionalized polymer. We specifically focused on highlighting the molecular pharmaceutics and mechanism in this study’s innovative findings. Journals from the Scopus, PubMed, and Google Scholar databases that were released during the last ten years were used to compile this review. According to inclusion and exclusion standards adjusted. This improved approach produced very impressive results, a very significant change in the characteristics of mesoporous silica that can affect effectiveness. Mesoporous silica approaches have the capacity to greatly enhance a drug’s physicochemical issues, boost therapeutic efficacy, and acquire superb features.Graphical Abstract: Keywords: mesoporous silica, polymer, ligand, lung cancer |
| first_indexed | 2024-03-11T21:38:02Z |
| format | Article |
| id | doaj.art-ac973b34fcb34f82b11b2dd6ebe92ce8 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-11T21:38:02Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-ac973b34fcb34f82b11b2dd6ebe92ce82023-09-26T18:27:38ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-09-01Volume 185473549386942How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the LiteratureBudiman ARusdin ASubra LAulifa DLArif Budiman,1,* Agus Rusdin,2,* Laila Subra,3 Diah Lia Aulifa2,* 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department of Pharmacy, faculty of Bioeconomic, Food and Health Sciences, Universiti Geomatika Malaysia, Kuala Lumpur, Malaysia*These authors contributed equally to this workCorrespondence: Diah Lia Aulifa, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km. 21, Sumedang, West Java, 45363, Indonesia, Email diah.lia@unpad.ac.idAbstract: In 2020, there were 2.21 million new instances of lung cancer, making it the top cause of mortality globally, responsible for close to 10 million deaths. The physicochemical problems of chemotherapy drugs are the primary challenge that now causes a drug’s low effectiveness. Solubility is a physicochemical factor that has a significant impact on a drug’s biopharmaceutical properties, starting with the rate at which it dissolves and extending through how well it is absorbed and bioavailable. One of the most well-known methods for addressing a drug’s solubility is mesoporous silica, which has undergone excellent development due to the conjugation of polymers and ligands that increase its effectiveness. However, there are still very few papers addressing the success of this discovery, particularly those addressing its molecular pharmaceutics and mechanism. Our study’s objectives were to explore and summarize the effects of targeting mediator on drug development using mesoporous silica with and without functionalized polymer. We specifically focused on highlighting the molecular pharmaceutics and mechanism in this study’s innovative findings. Journals from the Scopus, PubMed, and Google Scholar databases that were released during the last ten years were used to compile this review. According to inclusion and exclusion standards adjusted. This improved approach produced very impressive results, a very significant change in the characteristics of mesoporous silica that can affect effectiveness. Mesoporous silica approaches have the capacity to greatly enhance a drug’s physicochemical issues, boost therapeutic efficacy, and acquire superb features.Graphical Abstract: Keywords: mesoporous silica, polymer, ligand, lung cancerhttps://www.dovepress.com/how-key-alterations-of-mesoporous-silica-nanoparticles-affect-anti-lun-peer-reviewed-fulltext-article-IJNmesoporous silicapolymerligandand lung cancer |
| spellingShingle | Budiman A Rusdin A Subra L Aulifa DL How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature International Journal of Nanomedicine mesoporous silica polymer ligand and lung cancer |
| title | How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature |
| title_full | How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature |
| title_fullStr | How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature |
| title_full_unstemmed | How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature |
| title_short | How Key Alterations of Mesoporous Silica Nanoparticles Affect Anti-Lung Cancer Therapy? A Comprehensive Review of the Literature |
| title_sort | how key alterations of mesoporous silica nanoparticles affect anti lung cancer therapy a comprehensive review of the literature |
| topic | mesoporous silica polymer ligand and lung cancer |
| url | https://www.dovepress.com/how-key-alterations-of-mesoporous-silica-nanoparticles-affect-anti-lun-peer-reviewed-fulltext-article-IJN |
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