Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank
Summary: Background: Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. Methods: In primary analysis, we pooled individual-le...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
|
| Series: | The Lancet Regional Health. Europe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776222001119 |
| _version_ | 1828823415032643584 |
|---|---|
| author | Solja T. Nyberg G David Batty Jaana Pentti Ida E H Madsen Lars Alfredsson Jakob B. Bjorner Marianne Borritz Hermann Burr Jenni Ervasti Marcel Goldberg Markus Jokela Anders Knutsson Aki Koskinen Tea Lallukka Joni V. Lindbohm Martin L. Nielsen Tuula Oksanen Jan H. Pejtersen Olli Pietiläinen Ossi Rahkonen Reiner Rugulies Martin J. Shipley Pyry N. Sipilä Jeppe K. Sørensen Sari Stenholm Sakari Suominen Ari Väänänen Jussi Vahtera Marianna Virtanen Hugo Westerlund Marie Zins Archana Singh-Manoux Mika Kivimäki |
| author_facet | Solja T. Nyberg G David Batty Jaana Pentti Ida E H Madsen Lars Alfredsson Jakob B. Bjorner Marianne Borritz Hermann Burr Jenni Ervasti Marcel Goldberg Markus Jokela Anders Knutsson Aki Koskinen Tea Lallukka Joni V. Lindbohm Martin L. Nielsen Tuula Oksanen Jan H. Pejtersen Olli Pietiläinen Ossi Rahkonen Reiner Rugulies Martin J. Shipley Pyry N. Sipilä Jeppe K. Sørensen Sari Stenholm Sakari Suominen Ari Väänänen Jussi Vahtera Marianna Virtanen Hugo Westerlund Marie Zins Archana Singh-Manoux Mika Kivimäki |
| author_sort | Solja T. Nyberg |
| collection | DOAJ |
| description | Summary: Background: Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. Methods: In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study. Findings: During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, women 24·0 (21·4–26·5) years] and those with self-reported heavy overall consumption and binge drinking [men: 26·0 (25·3–26·8), women 27·5 (26·4–28·5) years]. The pattern of results for alcohol poisoning and self-reported alcohol consumption was similar in UK Biobank. In IPD-Work and UK Biobank, differences in disease-free years between self-reported moderate drinkers and heavy drinkers were 1·5 years or less. Interpretation: Individuals with alcohol poisonings or heavy self-reported overall consumption combined with a binge drinking habit have a marked 3- to 6-year loss in healthy longevity. Differences in disease-free life between categories of self-reported weekly alcohol consumption were smaller. Funding: Medical Research Council, National Institute on Aging, NordForsk, Academy of Finland, Finnish Work Environment Fund. |
| first_indexed | 2024-12-12T13:35:36Z |
| format | Article |
| id | doaj.art-ac981462042d400b93cb61367119b89e |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-12-12T13:35:36Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-ac981462042d400b93cb61367119b89e2022-12-22T00:22:58ZengElsevierThe Lancet Regional Health. Europe2666-77622022-08-0119100417Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK BiobankSolja T. Nyberg0G David Batty1Jaana Pentti2Ida E H Madsen3Lars Alfredsson4Jakob B. Bjorner5Marianne Borritz6Hermann Burr7Jenni Ervasti8Marcel Goldberg9Markus Jokela10Anders Knutsson11Aki Koskinen12Tea Lallukka13Joni V. Lindbohm14Martin L. Nielsen15Tuula Oksanen16Jan H. Pejtersen17Olli Pietiläinen18Ossi Rahkonen19Reiner Rugulies20Martin J. Shipley21Pyry N. Sipilä22Jeppe K. Sørensen23Sari Stenholm24Sakari Suominen25Ari Väänänen26Jussi Vahtera27Marianna Virtanen28Hugo Westerlund29Marie Zins30Archana Singh-Manoux31Mika Kivimäki32Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Faculty of Social Sciences, University of Tampere, Tampere, Finland; Finnish Institute of Occupational Health, Helsinki, Finland; Corresponding author at: Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland.Department of Epidemiology and Public Health, University College London, London, UKClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FinlandNational Research Centre for the Working Environment, Copenhagen, DenmarkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, SwedenNational Research Centre for the Working Environment, Copenhagen, DenmarkBispebjerg University Hospital, Copenhagen, DenmarkFederal Institute for Occupational Safety and Health (BAuA), Berlin, GermanyFinnish Institute of Occupational Health, Helsinki, FinlandParis Descartes University, Paris, France; Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, FranceDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, FinlandDepartment of Health Sciences, Mid Sweden University, Sundsvall, SwedenFinnish Institute of Occupational Health, Helsinki, FinlandClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, FinlandClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, FinlandAS3 Companies, Viby J, DenmarkInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandVIVE-The Danish Center for Social Science Research, Copenhagen, DenmarkClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, FinlandClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, FinlandNational Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, DenmarkDepartment of Epidemiology and Public Health, University College London, London, UKClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, FinlandNational Research Centre for the Working Environment, Copenhagen, DenmarkDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FinlandDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland; School of Health Science, University of Skövde, Skövde, SwedenFinnish Institute of Occupational Health, Helsinki, FinlandDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FinlandSchool of Educational Sciences and Psychology, University of Eastern Finland, Joensuu, Finland; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenStress Research Institute, Stockholm University, Stockholm, SwedenParis Descartes University, Paris, France; Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, FranceDepartment of Epidemiology and Public Health, University College London, London, UK; Inserm U1153, Epidemiology of Ageing and Neurodegenerative Diseases, Université de Paris, FranceClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Tukholmankatu 8B, FI-00014 Helsingin yliopisto, Helsinki, Finland; Department of Epidemiology and Public Health, University College London, London, UKSummary: Background: Heavy alcohol consumption increases the risk of several chronic diseases. In this multicohort study, we estimated the number of life-years without major chronic diseases according to different characteristics of alcohol use. Methods: In primary analysis, we pooled individual-level data from up to 129,942 adults across 12 cohort studies with baseline data collection on alcohol consumption, drinking patterns, and history between 1986 and 2005 (the IPD-Work Consortium). Self-reported alcohol consumption was categorised according to UK guidelines – non-drinking (never or former drinkers); moderate consumption (1–14 units); heavy consumption (>14 units per week). We further subdivided moderate and heavy drinkers by binge drinking pattern (alcohol-induced loss of consciousness). In addition, we assessed problem drinking using linked data on hospitalisations due to alcohol abuse or poisoning. Follow-up for chronic diseases for all participants included incident type 2 diabetes, coronary heart disease, stroke, cancer, and respiratory disease (asthma and chronic obstructive pulmonary disease) as ascertained via linkage to national morbidity and mortality registries, repeated medical examinations, and/or self-report. We estimated years lived without any of these diseases between 40 and 75 years of age according to sex and characteristics of alcohol use. We repeated the main analyses using data from 427,621 participants in the UK Biobank cohort study. Findings: During 1·73 million person-years at risk, 22,676 participants in IPD-Work cohorts developed at least one chronic condition. From age 40 to 75 years, never-drinkers [men: 29·3 (95%CI 27·9–30·8) years, women 29·8 (29·2–30·4) years)] and moderate drinkers with no binge drinking habit [men 28·7 (28·4–29·0) years, women 29·6 (29·4–29·7) years] had the longest disease-free life span. A much shorter disease-free life span was apparent in participants who experienced alcohol poisoning [men 23·4 (20·9–26·0) years, women 24·0 (21·4–26·5) years] and those with self-reported heavy overall consumption and binge drinking [men: 26·0 (25·3–26·8), women 27·5 (26·4–28·5) years]. The pattern of results for alcohol poisoning and self-reported alcohol consumption was similar in UK Biobank. In IPD-Work and UK Biobank, differences in disease-free years between self-reported moderate drinkers and heavy drinkers were 1·5 years or less. Interpretation: Individuals with alcohol poisonings or heavy self-reported overall consumption combined with a binge drinking habit have a marked 3- to 6-year loss in healthy longevity. Differences in disease-free life between categories of self-reported weekly alcohol consumption were smaller. Funding: Medical Research Council, National Institute on Aging, NordForsk, Academy of Finland, Finnish Work Environment Fund.http://www.sciencedirect.com/science/article/pii/S2666776222001119Alcohol consumptionBinge drinkingDisease-free life-yearsChronic diseases |
| spellingShingle | Solja T. Nyberg G David Batty Jaana Pentti Ida E H Madsen Lars Alfredsson Jakob B. Bjorner Marianne Borritz Hermann Burr Jenni Ervasti Marcel Goldberg Markus Jokela Anders Knutsson Aki Koskinen Tea Lallukka Joni V. Lindbohm Martin L. Nielsen Tuula Oksanen Jan H. Pejtersen Olli Pietiläinen Ossi Rahkonen Reiner Rugulies Martin J. Shipley Pyry N. Sipilä Jeppe K. Sørensen Sari Stenholm Sakari Suominen Ari Väänänen Jussi Vahtera Marianna Virtanen Hugo Westerlund Marie Zins Archana Singh-Manoux Mika Kivimäki Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank The Lancet Regional Health. Europe Alcohol consumption Binge drinking Disease-free life-years Chronic diseases |
| title | Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank |
| title_full | Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank |
| title_fullStr | Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank |
| title_full_unstemmed | Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank |
| title_short | Association of alcohol use with years lived without major chronic diseases: A multicohort study from the IPD-Work consortium and UK Biobank |
| title_sort | association of alcohol use with years lived without major chronic diseases a multicohort study from the ipd work consortium and uk biobank |
| topic | Alcohol consumption Binge drinking Disease-free life-years Chronic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2666776222001119 |
| work_keys_str_mv | AT soljatnyberg associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT gdavidbatty associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jaanapentti associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT idaehmadsen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT larsalfredsson associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jakobbbjorner associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT marianneborritz associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT hermannburr associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jenniervasti associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT marcelgoldberg associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT markusjokela associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT andersknutsson associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT akikoskinen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT tealallukka associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jonivlindbohm associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT martinlnielsen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT tuulaoksanen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT janhpejtersen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT ollipietilainen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT ossirahkonen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT reinerrugulies associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT martinjshipley associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT pyrynsipila associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jeppeksørensen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT saristenholm associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT sakarisuominen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT arivaananen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT jussivahtera associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT mariannavirtanen associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT hugowesterlund associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT mariezins associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT archanasinghmanoux associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank AT mikakivimaki associationofalcoholusewithyearslivedwithoutmajorchronicdiseasesamulticohortstudyfromtheipdworkconsortiumandukbiobank |