The Spirocyclic Imine from a Marine Benthic Dinoflagellate, Portimine, Is a Potent Anti-Human Immunodeficiency Virus Type 1 Therapeutic Lead Compound

The Spirocyclic Imine from a Marine Benthic Dinoflagellate, Portimine, Is a Potent Anti-Human Immunodeficiency Virus Type 1 Therapeutic Lead Compound

In this study, we aimed to find chemicals from lower sea animals with defensive effects against human immunodeficiency virus type 1 (HIV-1). A library of marine natural products consisting of 80 compounds was screened for activity against HIV-1 infection using a luciferase-encoding HIV-1 vector. We...

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Bibliographic Details
Main Authors: Mai Izumida, Koushirou Suga, Fumito Ishibashi, Yoshinao Kubo
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Marine Drugs
Subjects:
portimine
<i>Vulcanodinium rugosum</i>
HIV-1
reverse transcriptase
Online Access:https://www.mdpi.com/1660-3397/17/9/495

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