Neutrophils in malaria: A double-edged sword role
Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first line of defense against invading foreign pathogens and might play a crucial role in malaria. According to World Health Organization (WHO), malaria is a globally significant disease caused by protozoan parasit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.922377/full |
| _version_ | 1811311550294654976 |
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| author | Kehinde Adebayo Babatunde Kehinde Adebayo Babatunde Oluwadamilola Fatimat Adenuga |
| author_facet | Kehinde Adebayo Babatunde Kehinde Adebayo Babatunde Oluwadamilola Fatimat Adenuga |
| author_sort | Kehinde Adebayo Babatunde |
| collection | DOAJ |
| description | Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first line of defense against invading foreign pathogens and might play a crucial role in malaria. According to World Health Organization (WHO), malaria is a globally significant disease caused by protozoan parasites from the Plasmodium genus, and it’s responsible for 627,000 deaths in 2020. Neutrophils participate in the defense response against the malaria parasite via phagocytosis and reactive oxygen species (ROS) production. Neutrophils might also be involved in the pathogenesis of malaria by the release of toxic granules and the release of neutrophil extracellular traps (NETs). Intriguingly, malaria parasites inhibit the anti-microbial function of neutrophils, thus making malaria patients more susceptible to secondary opportunistic Salmonella infections. In this review, we will provide a summary of the role of neutrophils during malaria infection, some contradicting mouse model neutrophil data and neutrophil-related mechanisms involved in malaria patients’ susceptibility to bacterial infection. |
| first_indexed | 2024-04-13T10:19:56Z |
| format | Article |
| id | doaj.art-ac994d3fb36446758b15ac70449fae18 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T10:19:56Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ac994d3fb36446758b15ac70449fae182022-12-22T02:50:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-07-011310.3389/fimmu.2022.922377922377Neutrophils in malaria: A double-edged sword roleKehinde Adebayo Babatunde0Kehinde Adebayo Babatunde1Oluwadamilola Fatimat Adenuga2Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaDepartment of Pathology & Laboratory Medicine, University of Wisconsin, Madison, WI, United StatesDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, United StatesNeutrophils are the most abundant leukocytes in human peripheral blood. They form the first line of defense against invading foreign pathogens and might play a crucial role in malaria. According to World Health Organization (WHO), malaria is a globally significant disease caused by protozoan parasites from the Plasmodium genus, and it’s responsible for 627,000 deaths in 2020. Neutrophils participate in the defense response against the malaria parasite via phagocytosis and reactive oxygen species (ROS) production. Neutrophils might also be involved in the pathogenesis of malaria by the release of toxic granules and the release of neutrophil extracellular traps (NETs). Intriguingly, malaria parasites inhibit the anti-microbial function of neutrophils, thus making malaria patients more susceptible to secondary opportunistic Salmonella infections. In this review, we will provide a summary of the role of neutrophils during malaria infection, some contradicting mouse model neutrophil data and neutrophil-related mechanisms involved in malaria patients’ susceptibility to bacterial infection.https://www.frontiersin.org/articles/10.3389/fimmu.2022.922377/fullneutrophilmalariaplasmodiumsalmonella typhimuriumneutrophil extracellular traps (NETs) |
| spellingShingle | Kehinde Adebayo Babatunde Kehinde Adebayo Babatunde Oluwadamilola Fatimat Adenuga Neutrophils in malaria: A double-edged sword role Frontiers in Immunology neutrophil malaria plasmodium salmonella typhimurium neutrophil extracellular traps (NETs) |
| title | Neutrophils in malaria: A double-edged sword role |
| title_full | Neutrophils in malaria: A double-edged sword role |
| title_fullStr | Neutrophils in malaria: A double-edged sword role |
| title_full_unstemmed | Neutrophils in malaria: A double-edged sword role |
| title_short | Neutrophils in malaria: A double-edged sword role |
| title_sort | neutrophils in malaria a double edged sword role |
| topic | neutrophil malaria plasmodium salmonella typhimurium neutrophil extracellular traps (NETs) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.922377/full |
| work_keys_str_mv | AT kehindeadebayobabatunde neutrophilsinmalariaadoubleedgedswordrole AT kehindeadebayobabatunde neutrophilsinmalariaadoubleedgedswordrole AT oluwadamilolafatimatadenuga neutrophilsinmalariaadoubleedgedswordrole |