The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence
Radiation therapy is an important modality used in the treatment of patients with brain metastatic disease and malignant gliomas. Post-treatment surveillance often involves serial magnetic resonance imaging. A challenge faced by clinicians is in the diagnosis and management of a suspicious gadoliniu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/15/7/11832 |
| _version_ | 1811260251303837696 |
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| author | Kashif Parvez Aatif Parvez Gelareh Zadeh |
| author_facet | Kashif Parvez Aatif Parvez Gelareh Zadeh |
| author_sort | Kashif Parvez |
| collection | DOAJ |
| description | Radiation therapy is an important modality used in the treatment of patients with brain metastatic disease and malignant gliomas. Post-treatment surveillance often involves serial magnetic resonance imaging. A challenge faced by clinicians is in the diagnosis and management of a suspicious gadolinium-enhancing lesion found on imaging. The suspicious lesion may represent post-treatment radiation effects (PTRE) such as pseudoprogression, radiation necrosis or tumor recurrence. Significant progress has been made in diagnostic imaging modalities to assist in differentiating these entities. Surgical and medical interventions have also been developed to treat PTRE. In this review, we discuss the pathophysiology, clinical presentation, diagnostic imaging modalities and provide an algorithm for the management of pseudoprogression, radiation necrosis and tumor recurrence. |
| first_indexed | 2024-04-12T18:44:38Z |
| format | Article |
| id | doaj.art-ac9995806eae407fbe28e073548dbf15 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T18:44:38Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ac9995806eae407fbe28e073548dbf152022-12-22T03:20:40ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-07-01157118321184610.3390/ijms150711832ijms150711832The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor RecurrenceKashif Parvez0Aatif Parvez1Gelareh Zadeh2Division of Neurosurgery, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, CanadaDepartment of Medical Imaging, Royal University Hospital, University of Saskatchewan, Saskatoon, SK S7N 0W8, CanadaDivision of Neurosurgery, University Health Network, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, CanadaRadiation therapy is an important modality used in the treatment of patients with brain metastatic disease and malignant gliomas. Post-treatment surveillance often involves serial magnetic resonance imaging. A challenge faced by clinicians is in the diagnosis and management of a suspicious gadolinium-enhancing lesion found on imaging. The suspicious lesion may represent post-treatment radiation effects (PTRE) such as pseudoprogression, radiation necrosis or tumor recurrence. Significant progress has been made in diagnostic imaging modalities to assist in differentiating these entities. Surgical and medical interventions have also been developed to treat PTRE. In this review, we discuss the pathophysiology, clinical presentation, diagnostic imaging modalities and provide an algorithm for the management of pseudoprogression, radiation necrosis and tumor recurrence.http://www.mdpi.com/1422-0067/15/7/11832pseudoprogressionradiation necrosismetastasisgliomarecurrence |
| spellingShingle | Kashif Parvez Aatif Parvez Gelareh Zadeh The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence International Journal of Molecular Sciences pseudoprogression radiation necrosis metastasis glioma recurrence |
| title | The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence |
| title_full | The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence |
| title_fullStr | The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence |
| title_full_unstemmed | The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence |
| title_short | The Diagnosis and Treatment of Pseudoprogression, Radiation Necrosis and Brain Tumor Recurrence |
| title_sort | diagnosis and treatment of pseudoprogression radiation necrosis and brain tumor recurrence |
| topic | pseudoprogression radiation necrosis metastasis glioma recurrence |
| url | http://www.mdpi.com/1422-0067/15/7/11832 |
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