QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities

QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities

Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the...

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Bibliographic Details
Main Authors: Marilia N. N. Lima, Cleber C. Melo-Filho, Gustavo C. Cassiano, Bruno J. Neves, Vinicius M. Alves, Rodolpho C. Braga, Pedro V. L. Cravo, Eugene N. Muratov, Juliana Calit, Daniel Y. Bargieri, Fabio T. M. Costa, Carolina H. Andrade
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
malaria
virtual screening
QSAR
Plasmodium falciparum
dUTPase
transmission blocker
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00146/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00146/full

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