NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification
Abstract Posterior capsule opacification (PCO) is the most common complication after cataract surgery. Drug-eluting intraocular lens (IOLs) is a promising concept of PCO treatment in modern cataract surgery. However, the large dose of drugs in IOL leads to uncontrollable and unpredictable drug relea...
| Główni autorzy: | , , , , , , |
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| Format: | Artykuł |
| Język: | English |
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BMC
2023-09-01
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| Seria: | Journal of Nanobiotechnology |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1186/s12951-023-02055-2 |
| _version_ | 1827708621602947072 |
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| author | Chen Qin Shimin Wen Fan Fei Yuemei Han Haiting Wang Hao Chen Quankui Lin |
| author_facet | Chen Qin Shimin Wen Fan Fei Yuemei Han Haiting Wang Hao Chen Quankui Lin |
| author_sort | Chen Qin |
| collection | DOAJ |
| description | Abstract Posterior capsule opacification (PCO) is the most common complication after cataract surgery. Drug-eluting intraocular lens (IOLs) is a promising concept of PCO treatment in modern cataract surgery. However, the large dose of drugs in IOL leads to uncontrollable and unpredictable drug release, which inevitably brings risks of overtreatment and ocular toxicity. Herein, a low-power NIR-triggered thermosensitive IOL named IDG@P(NIPAM-co-AA)-IOL is proposed to improve security and prevent PCO by synergetic controlled drug therapy and simultaneous photo-therapy. Thermosensitive polymer brushes Poly(N-isopropylacrylamide-co-Acrylic acid) (P(NIPAM-co-AA)) is prepared on IOL via surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization. Then, Doxorubicin (DOX) and Indocyanine green (ICG) co-loaded Gelatin NPs (IDG NPs) are loaded in P(NIPAM-co-AA) by temperature control. The IDG NPs perform in suit photodynamic & photothermal therapy (PTT&PDT), and the produced heat also provides a trigger for controllable drug therapy with a cascade effect. Such functional IOL shows excellent synergistic drug-phototherapy effect and NIR-triggered drug release behavior. And there is no obvious PCO occurrence in IDG@P(NIPAM-co-AA) IOL under NIR irradiation compared with control group. This proposed IDG@P(NIPAM-co-AA)-IOL serves as a promising platform that combines phototherapy and drug-therapy to enhance the therapeutic potential and medication safety for future clinical application of PCO treatment. |
| first_indexed | 2024-03-10T17:07:09Z |
| format | Article |
| id | doaj.art-ac9e33205421419394ec710df42e124e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:07:09Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-ac9e33205421419394ec710df42e124e2023-11-20T10:47:29ZengBMCJournal of Nanobiotechnology1477-31552023-09-0121112010.1186/s12951-023-02055-2NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacificationChen Qin0Shimin Wen1Fan Fei2Yuemei Han3Haiting Wang4Hao Chen5Quankui Lin6National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityNational Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical UniversityAbstract Posterior capsule opacification (PCO) is the most common complication after cataract surgery. Drug-eluting intraocular lens (IOLs) is a promising concept of PCO treatment in modern cataract surgery. However, the large dose of drugs in IOL leads to uncontrollable and unpredictable drug release, which inevitably brings risks of overtreatment and ocular toxicity. Herein, a low-power NIR-triggered thermosensitive IOL named IDG@P(NIPAM-co-AA)-IOL is proposed to improve security and prevent PCO by synergetic controlled drug therapy and simultaneous photo-therapy. Thermosensitive polymer brushes Poly(N-isopropylacrylamide-co-Acrylic acid) (P(NIPAM-co-AA)) is prepared on IOL via surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization. Then, Doxorubicin (DOX) and Indocyanine green (ICG) co-loaded Gelatin NPs (IDG NPs) are loaded in P(NIPAM-co-AA) by temperature control. The IDG NPs perform in suit photodynamic & photothermal therapy (PTT&PDT), and the produced heat also provides a trigger for controllable drug therapy with a cascade effect. Such functional IOL shows excellent synergistic drug-phototherapy effect and NIR-triggered drug release behavior. And there is no obvious PCO occurrence in IDG@P(NIPAM-co-AA) IOL under NIR irradiation compared with control group. This proposed IDG@P(NIPAM-co-AA)-IOL serves as a promising platform that combines phototherapy and drug-therapy to enhance the therapeutic potential and medication safety for future clinical application of PCO treatment.https://doi.org/10.1186/s12951-023-02055-2Posterior capsule opacificationDrug-phototherapyThermosensitive coatingControllable drug releaseSI-RAFT |
| spellingShingle | Chen Qin Shimin Wen Fan Fei Yuemei Han Haiting Wang Hao Chen Quankui Lin NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification Journal of Nanobiotechnology Posterior capsule opacification Drug-phototherapy Thermosensitive coating Controllable drug release SI-RAFT |
| title | NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| title_full | NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| title_fullStr | NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| title_full_unstemmed | NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| title_short | NIR-triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| title_sort | nir triggered thermosensitive polymer brush coating modified intraocular lens for smart prevention of posterior capsular opacification |
| topic | Posterior capsule opacification Drug-phototherapy Thermosensitive coating Controllable drug release SI-RAFT |
| url | https://doi.org/10.1186/s12951-023-02055-2 |
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