Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study
Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pathophysiology |
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| Online Access: | https://www.mdpi.com/1873-149X/29/4/46 |
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| author | Tatyana Bukkieva Maria Pospelova Aleksandr Efimtsev Olga Fionik Tatyana Alekseeva Konstantin Samochernykh Elena Gorbunova Varvara Krasnikova Albina Makhanova Aleksandra Nikolaeva Samvel Tonyan Anna Lepekhina Anatoliy Levchuk Gennadiy Trufanov Serik Akshulakov Maxim Shevtsov |
| author_facet | Tatyana Bukkieva Maria Pospelova Aleksandr Efimtsev Olga Fionik Tatyana Alekseeva Konstantin Samochernykh Elena Gorbunova Varvara Krasnikova Albina Makhanova Aleksandra Nikolaeva Samvel Tonyan Anna Lepekhina Anatoliy Levchuk Gennadiy Trufanov Serik Akshulakov Maxim Shevtsov |
| author_sort | Tatyana Bukkieva |
| collection | DOAJ |
| description | Complex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (<i>n</i> = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (<i>n</i> = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer. |
| first_indexed | 2024-03-09T15:59:35Z |
| format | Article |
| id | doaj.art-ac9e56dd12b04898a9046aca4a707b55 |
| institution | Directory Open Access Journal |
| issn | 1873-149X |
| language | English |
| last_indexed | 2024-03-09T15:59:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathophysiology |
| spelling | doaj.art-ac9e56dd12b04898a9046aca4a707b552023-11-24T17:14:50ZengMDPI AGPathophysiology1873-149X2022-10-0129459560910.3390/pathophysiology29040046Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging StudyTatyana Bukkieva0Maria Pospelova1Aleksandr Efimtsev2Olga Fionik3Tatyana Alekseeva4Konstantin Samochernykh5Elena Gorbunova6Varvara Krasnikova7Albina Makhanova8Aleksandra Nikolaeva9Samvel Tonyan10Anna Lepekhina11Anatoliy Levchuk12Gennadiy Trufanov13Serik Akshulakov14Maxim Shevtsov15Personalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaNational Center for Neurosurgery, Turan Ave., 34/1, Nur-Sultan 010000, KazakhstanPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 St. Petersburg, RussiaComplex breast cancer (BC) treatment can cause various neurological and psychiatric complications, such as postmastectomy pain syndrome, vestibulocerebellar ataxia, and depression, which can lead to microstructural damage of the white matter tracts of the brain. The purpose of the study is to assess microstructural changes in the white matter tracts of the brain in BC survivors using diffusion tensor imaging (DTI). Single DTI scans were performed on patients (<i>n</i> = 84) after complex BC treatment (i.e., surgery, chemotherapy and/or radiation therapy) and on the control group (<i>n</i> = 40). According to the results, a decrease in the quantitative anisotropy (FDR ≤ 0.05) was revealed in the bilateral corticospinal tracts, cerebellar tracts, corpus callosum, fornix, left superior corticostriatal and left corticopontine parietal in patients after BC treatment in comparison to the control group. A decrease in the quantitative anisotropy (FDR ≤ 0.05) was also revealed in the corpus callosum and right cerebellar tracts in patients after BC treatment with the presence of postmastectomy pain syndrome and vestibulocerebellar ataxia. The use of DTI in patients after BC treatment reveals microstructural properties of the white matter tracts in the brain. The results will allow for the improvement of treatment and rehabilitation approaches in patients receiving treatment for breast cancer.https://www.mdpi.com/1873-149X/29/4/46breast cancerbreast cancer treatmentpost-mastectomy pain syndromediffusion tensor imagingwhite matter tractsconnectome |
| spellingShingle | Tatyana Bukkieva Maria Pospelova Aleksandr Efimtsev Olga Fionik Tatyana Alekseeva Konstantin Samochernykh Elena Gorbunova Varvara Krasnikova Albina Makhanova Aleksandra Nikolaeva Samvel Tonyan Anna Lepekhina Anatoliy Levchuk Gennadiy Trufanov Serik Akshulakov Maxim Shevtsov Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study Pathophysiology breast cancer breast cancer treatment post-mastectomy pain syndrome diffusion tensor imaging white matter tracts connectome |
| title | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
| title_full | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
| title_fullStr | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
| title_full_unstemmed | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
| title_short | Microstructural Properties of Brain White Matter Tracts in Breast Cancer Survivors: A Diffusion Tensor Imaging Study |
| title_sort | microstructural properties of brain white matter tracts in breast cancer survivors a diffusion tensor imaging study |
| topic | breast cancer breast cancer treatment post-mastectomy pain syndrome diffusion tensor imaging white matter tracts connectome |
| url | https://www.mdpi.com/1873-149X/29/4/46 |
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